{"id":"W3197804316","doi":"10.1101/2021.09.07.459293","title":"Selective activation of BK channels in small-headed dendritic spines suppresses excitatory postsynaptic potentials","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Dendritic spine; Excitatory postsynaptic potential; Postsynaptic potential; Neuroscience; Neurotransmission; SPINE (molecular biology); Dendrite (mathematics); Chemistry; Biophysics; Anatomy; Biology; Inhibitory postsynaptic potential; Receptor; Hippocampal formation; Cell biology; Geometry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006008322,0.000137362,0.0003231461,0.00009273108,0.0001382311,0.0002750053,0.0002264141,0.0002460529,0.001522177],"category_scores_gemma":[0.000274755,0.00008767255,0.0001558159,0.00006996431,0.0002307332,0.0002260364,0.0002473788,0.0004163428,0.0002942187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001650607,"about_ca_system_score_gemma":0.0001715401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017552,"about_ca_topic_score_gemma":0.0003620407,"domain_scores_codex":[0.999908,0.0000072375,0.000008523314,0.00001573329,0.00002837495,0.00003207873],"domain_scores_gemma":[0.9998294,0.00004024233,0.00003220725,0.00001650131,0.00003071512,0.00005085123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001094547,0.00002067884,0.0001847675,0.00002679507,0.000003014738,0.00003027503,0.000008405671,0.00005198021,0.9989254,0.00006139778,0.00002532123,0.0005525276],"study_design_scores_gemma":[0.00009162207,0.0003552953,0.0158725,0.0000127893,0.00002764968,0.0002785938,0.00006906388,0.007368398,0.9745795,0.0003449356,0.0009885101,0.00001118394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997844,0.0003133024,0.001097133,0.00004132271,0.00002199661,0.000009663941,0.00007465426,0.00003474647,0.0005631399],"genre_scores_gemma":[0.9991512,0.0001223791,0.00032322,0.00002121149,0.000005038337,0.00000836417,0.00003553611,0.000006439961,0.0003265612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522177,"threshold_uncertainty_score":0.005092204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04553431021208444,"score_gpt":0.2878253127142726,"score_spread":0.2422910025021882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}