{"id":"W3197804636","doi":"10.1084/jem.20200853","title":"Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"High-end Foreign Experts Recruitment Plan of China; Labex Immuno-Oncology; European Research Area Network on Cardiovascular Diseases; Dalhousie Medical Research Foundation; Chancellerie des Universités de Paris; Institut Universitaire de France; Labex; Ligue Contre le Cancer; Fondation pour la Recherche Médicale; Horizon 2020 Framework Programme; Fondation de l'Avenir pour la Recherche Médicale Appliquée; Cancéropôle Ile de France; Dalhousie University; Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Institut Gustave-Roussy; Agence Nationale de la Recherche; Fondation Leducq; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canadian Cancer Society; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer; Seerave Foundation; European Commission; E-Rare","keywords":"Immunosurveillance; Autoimmunity; Context (archaeology); Biliary tract; Immunology; Primary sclerosing cholangitis; Cancer research; Biology; Medicine; Immune system; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002127853,0.0001576132,0.0004421086,0.0000428455,0.0003034106,0.00001007703,0.0004404099,0.00003900511,0.0004381276],"category_scores_gemma":[0.0005069859,0.00005967887,0.0002336811,0.0003029361,0.0005771527,0.00009559277,0.0001409127,0.0006638932,0.000003365401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007327509,"about_ca_system_score_gemma":0.0001710901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000275866,"about_ca_topic_score_gemma":0.000001418415,"domain_scores_codex":[0.9978399,0.0007730766,0.0005825072,0.00007432244,0.0005408358,0.0001894091],"domain_scores_gemma":[0.9974314,0.001041881,0.0005008951,0.0006812743,0.0002634369,0.00008111047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009667896,0.000787825,0.02671182,0.0000605477,0.0004894157,0.0001032319,0.0146679,0.000006556385,0.9519678,0.00005761533,0.001771604,0.002408867],"study_design_scores_gemma":[0.002738191,0.00164573,0.736006,0.0005399077,0.000416424,0.003176791,0.05342295,0.00002790489,0.2011617,0.00005764029,0.0007235922,0.00008308642],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9122581,0.0796359,0.0000123527,0.005858068,0.0004960948,0.0002061402,0.000003089699,0.000006988164,0.001523277],"genre_scores_gemma":[0.9974562,0.0009891638,0.00002678456,0.0009263534,0.000442563,0.000001887361,0.000003817744,0.00001613213,0.0001371135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7508061,"threshold_uncertainty_score":0.479719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02880704544254058,"score_gpt":0.3088946662883049,"score_spread":0.2800876208457643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}