{"id":"W3197866041","doi":"10.1038/s42003-021-02566-4","title":"Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Medical Research Council; Queen's University; King's College London; Research Councils UK; Public Health England; Department of Health and Social Care; National Institute for Health and Care Research; British Heart Foundation; Wellcome Trust; Francis Crick Institute; Cancer Research UK; Wellcome","keywords":"Efflux; Pseudomonas aeruginosa; Biology; Microbiology; Repressor; ATP synthase; Gene; Cell biology; Genetics; Bacteria; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702258,0.00009659441,0.0001679187,0.00004343241,0.00008430769,0.000009547297,0.0003479582,0.0001342836,0.00001010202],"category_scores_gemma":[0.0001751217,0.0001012747,0.00003878477,0.0001304224,0.0001989932,0.000003116685,0.0004466173,0.00007090573,0.000004644849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009562614,"about_ca_system_score_gemma":0.00005205626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002134182,"about_ca_topic_score_gemma":0.00007545823,"domain_scores_codex":[0.9991662,0.0001858008,0.0002494898,0.0002331652,0.0000361871,0.0001291417],"domain_scores_gemma":[0.9983972,0.00006784869,0.00009139938,0.001152263,0.000241392,0.00004993667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002249482,0.00007642084,0.007727962,0.00001489809,0.00003219355,3.027525e-7,0.00004497365,0.00001119447,0.9846414,0.005393993,0.00008044381,0.001953665],"study_design_scores_gemma":[0.0008659897,0.000275894,0.01101733,0.00006673498,0.00004744104,0.00007205545,0.0001393077,0.001895536,0.9494208,0.001892466,0.03398343,0.0003229878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718763,0.001867794,0.02334594,0.001428992,0.00006871299,0.0001473574,0.00002118901,0.0000104974,0.001233242],"genre_scores_gemma":[0.9655293,0.001633803,0.03203154,0.0001567238,0.00002488254,0.000008164029,0.0004026097,0.00001092848,0.0002020508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03522063,"threshold_uncertainty_score":0.4129862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275514860039948,"score_gpt":0.2915300783803497,"score_spread":0.2687749297799503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}