{"id":"W3197908941","doi":"10.1172/jci150143","title":"Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Sidra Medicine; National Health and Medical Research Council; National Institute of Allergy and Infectious Diseases; NSW Ministry of Health; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Hospital for Sick Children; US-UK Fulbright Commission; St. Giles Foundation","keywords":"Immunology; Biology; Myeloid; Innate lymphoid cell; T cell; CD8; Cytotoxic T cell; Acquired immune system; CD86; Immunity; Antigen; Immune system; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001972854,0.001354813,0.0004407976,0.0005281727,0.0005510075,0.0003056189,0.0003210571,0.000615762,0.0009700929],"category_scores_gemma":[0.0006454139,0.0003102237,0.0003468957,0.0003666862,0.0007287608,0.0002755015,0.0003423659,0.0007191124,0.0002754253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003142327,"about_ca_system_score_gemma":0.0003328504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002597764,"about_ca_topic_score_gemma":0.002019139,"domain_scores_codex":[0.9997225,0.00004507821,0.00002914401,0.00006370848,0.00004608361,0.00009332239],"domain_scores_gemma":[0.9996792,0.0001018059,0.00009437767,0.00001820648,0.00002484348,0.00008167036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001274774,0.001146591,0.09845062,0.0003090185,0.0001630718,0.590575,0.001988828,0.001602269,0.2850804,0.001500258,0.001328147,0.01658109],"study_design_scores_gemma":[0.0001697448,0.00252016,0.1144233,0.0000854366,0.0002089542,0.8282444,0.0007328228,0.002095931,0.04617838,0.0003235565,0.004965453,0.00005189707],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985939,0.0003024492,0.0003987544,0.00008550789,0.00001314526,0.00001120111,0.0001237015,0.00003146817,0.0004399269],"genre_scores_gemma":[0.998677,0.0002983711,0.0004959536,0.00004110327,0.00001689589,0.000005434268,0.0001080969,0.00001359977,0.0003436019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002597764,"threshold_uncertainty_score":0.005165279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06845582114287183,"score_gpt":0.358272995842323,"score_spread":0.2898171746994511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}