{"id":"W3197965471","doi":"10.1101/2021.08.27.21262722","title":"Risk of Serious Infections in Patients with Psoriasis on Biologic Therapies: An Updated Systematic Review and Meta-Analysis","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"LEO Pharma; Swedish Orphan Biovitrum; Bristol-Myers Squibb; Eli Lilly and Company; Galderma; Cilag; University of Manchester; British Association of Dermatologists; National Institute for Health and Care Research; Medical Research Council; Celgene; Sanofi; Pfizer; King's College London","keywords":"Medicine; Secukinumab; Adalimumab; Etanercept; Ixekizumab; Certolizumab pegol; Infliximab; Ustekinumab; Placebo; Internal medicine; Psoriasis; Anakinra; Odds ratio; Meta-analysis; Dermatology; Psoriatic arthritis; Rheumatoid arthritis; Tumor necrosis factor alpha; Alternative medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01361252,0.002872245,0.02015363,0.009900765,0.0005227363,0.003419227,0.002010121,0.002095061,0.002977781],"category_scores_gemma":[0.03127222,0.001844712,0.04708036,0.008749399,0.0006254436,0.001975924,0.001709912,0.002169773,0.000275339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002463299,"about_ca_system_score_gemma":0.003453971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006879287,"about_ca_topic_score_gemma":0.01218647,"domain_scores_codex":[0.9883896,0.004780494,0.003924488,0.001160487,0.0014131,0.0003318391],"domain_scores_gemma":[0.9780929,0.01477855,0.004105907,0.0006804299,0.002073798,0.000268386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001665711,0.00002407222,0.004153873,0.2796561,0.7025627,0.0001284845,0.00005636125,0.0003932249,0.000132627,0.00008873502,0.0005334787,0.01060471],"study_design_scores_gemma":[0.0005007271,0.0001111661,0.003342252,0.01774787,0.9768475,0.0001291516,0.00002538237,0.000137726,0.00006867607,0.0001291422,0.0009378204,0.00002252509],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.003702288,0.9948717,0.0004061045,0.0001351897,0.0001268602,0.0001552203,0.0004331549,0.0000195902,0.0001498305],"genre_scores_gemma":[0.1374145,0.8576491,0.001949533,0.0007895832,0.0003004297,0.0007440381,0.0008978031,0.00003304268,0.0002219645],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02015363,"threshold_uncertainty_score":0.07199067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02456300753205145,"score_gpt":0.25576989783601,"score_spread":0.2312068903039586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}