{"id":"W3197973059","doi":"10.1053/j.gastro.2021.08.045","title":"PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia","funders":"","keywords":"Medicine; Ulcerative colitis; Pharmacokinetics; Pharmacodynamics; Clinical trial; Placebo; Phases of clinical research; Dosing; Clinical endpoint; Oral administration; Antagonist; Pharmacology; Internal medicine; Colitis; Gastroenterology; Disease; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001594077,0.001118055,0.001040581,0.0006411673,0.0003234636,0.0009986907,0.0009188775,0.001250286,0.001975204],"category_scores_gemma":[0.0006341315,0.0004827789,0.0007239038,0.0005984257,0.0008928967,0.0007069481,0.000325429,0.002677102,0.0005513014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006193491,"about_ca_system_score_gemma":0.001119021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007777939,"about_ca_topic_score_gemma":0.002043254,"domain_scores_codex":[0.9995928,0.000153171,0.00002373783,0.00006163646,0.00008841891,0.00008017709],"domain_scores_gemma":[0.9995541,0.00007414196,0.0001062849,0.00004591381,0.00005471559,0.00016483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04152224,0.04553983,0.004623669,0.001960592,0.0007361182,0.0009313823,0.0005552592,0.006370761,0.6644681,0.0006320828,0.004907647,0.2277525],"study_design_scores_gemma":[0.06810671,0.7146807,0.02954444,0.0002437337,0.001008012,0.002854471,0.0001577979,0.003675075,0.1603326,0.0006968502,0.0185863,0.0001133808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768683,0.01288392,0.003484072,0.0006977684,0.00009211864,0.001760509,0.001121816,0.0002537396,0.002837848],"genre_scores_gemma":[0.9723386,0.0128132,0.004951473,0.001080134,0.0001226921,0.001580894,0.003596976,0.00008096416,0.003435046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975204,"threshold_uncertainty_score":0.008430421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04298130560540184,"score_gpt":0.356179756752572,"score_spread":0.3131984511471701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}