{"id":"W3197973059","doi":"10.1053/j.gastro.2021.08.045","title":"PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia","funders":"","keywords":"Medicine; Ulcerative colitis; Pharmacokinetics; Pharmacodynamics; Clinical trial; Placebo; Phases of clinical research; Dosing; Clinical endpoint; Oral administration; Antagonist; Pharmacology; Internal medicine; Colitis; Gastroenterology; Disease; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002671227,0.0001655646,0.0002432714,0.00002722157,0.00008729029,0.00002115153,0.00006564048,0.00009653991,0.00001891543],"category_scores_gemma":[0.0001067603,0.0001715168,0.00002723763,0.00002338893,0.0003394282,0.000006970826,0.000237206,0.0001041218,0.000002261178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002078813,"about_ca_system_score_gemma":0.00009706715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003490419,"about_ca_topic_score_gemma":0.004518359,"domain_scores_codex":[0.9984622,0.0003514128,0.0003024426,0.0004770602,0.00006147295,0.0003454328],"domain_scores_gemma":[0.9995106,0.0000142052,0.00006154,0.0001815186,0.00008541053,0.0001467569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006294137,0.0007156488,0.9722632,0.0001141949,0.0003776466,0.002117598,0.001604218,0.00001626048,0.0110875,0.0001174915,0.001896283,0.00339579],"study_design_scores_gemma":[0.006436733,0.001210768,0.9830073,0.00002697844,0.00003440044,0.0003056697,0.001191755,0.00004071456,0.003050525,0.00007953184,0.004434056,0.0001816349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991743,0.0002231184,0.00006152791,0.0001806659,0.0001211131,0.0001465207,0.00003953854,0.000008154726,0.00004505313],"genre_scores_gemma":[0.996395,0.0001861747,0.002032809,0.0008964234,0.00009765202,0.00005040508,0.0001723528,0.00001395124,0.0001552596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.010744,"threshold_uncertainty_score":0.6994253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04298130560540184,"score_gpt":0.356179756752572,"score_spread":0.3131984511471701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}