{"id":"W3198099965","doi":"10.15252/emmm.202114392","title":"Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canton de Fribourg; Agence Nationale de la Recherche; Debra International; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation","keywords":"Fibrosis; Extracellular matrix; Medicine; Immunity; Cancer research; Inflammation; Immunology; Fibroblast; Immune system; Pathology; Biology; Cell biology; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283405,0.0002905008,0.0002665709,0.0002332386,0.0001312463,0.0002610432,0.0001290509,0.0002360179,0.001052423],"category_scores_gemma":[0.0001256361,0.00009719795,0.0001954809,0.00007120887,0.0003116891,0.0002033905,0.0001937561,0.000672457,0.0001516886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234466,"about_ca_system_score_gemma":0.0001723427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001928318,"about_ca_topic_score_gemma":0.0004554487,"domain_scores_codex":[0.9998479,0.00005294425,0.00001281801,0.00002928128,0.00002746706,0.0000295436],"domain_scores_gemma":[0.9998739,0.00001815156,0.00004943624,0.00001035123,0.000007112436,0.00004095415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002162358,0.0000745751,0.0002461303,0.00003430885,0.00000604424,0.00005528226,0.00001505573,0.00003214518,0.9978416,0.00005429657,0.00002049202,0.001403784],"study_design_scores_gemma":[0.00007608878,0.00267225,0.0124625,0.00002080074,0.00005297304,0.0007923814,0.00009770375,0.001001847,0.9805624,0.0001419209,0.002109138,0.000009858125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996421,0.001243499,0.001413295,0.0000991589,0.00003047996,0.00002283852,0.0001121226,0.00007053697,0.0005869793],"genre_scores_gemma":[0.9967477,0.0007705122,0.001296185,0.0000475084,0.00001432172,0.00002735835,0.00008686825,0.00001155233,0.0009978855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001052423,"threshold_uncertainty_score":0.003520668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008732242952953832,"score_gpt":0.278689936454477,"score_spread":0.2699576935015232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}