{"id":"W3198104775","doi":"10.1002/hep4.1799","title":"Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"AMPK; Inflammation; Hepatic stellate cell; Insulin resistance; Lipogenesis; Nonalcoholic fatty liver disease; Endocrinology; Internal medicine; Steatosis; Fatty liver; Adipose tissue; Biology; Protein kinase A; Medicine; Cell biology; Kinase; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007650702,0.0001317063,0.0003100702,0.000106278,0.0001698825,0.00002076092,0.00006008216,0.00009916605,0.000009832544],"category_scores_gemma":[0.0002333744,0.0001264118,0.00004228074,0.00025022,0.00008028095,0.0001581791,0.0001057118,0.0001149662,0.00001044543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007733552,"about_ca_system_score_gemma":0.00007266327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002829453,"about_ca_topic_score_gemma":0.0005102401,"domain_scores_codex":[0.9989753,0.0003600966,0.0001862682,0.0002477902,0.00009878337,0.0001317654],"domain_scores_gemma":[0.9984425,0.0006906725,0.00008322128,0.0006411719,0.000077541,0.00006491932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001081495,0.0008541422,0.9555119,0.0001417701,0.0002987206,0.00002603781,0.0009412556,0.000005385271,0.005508547,0.002526973,0.0001644508,0.03391269],"study_design_scores_gemma":[0.001513447,0.00008799799,0.9076682,0.0002133969,0.0003007172,0.00003036421,0.0001044545,0.0004458725,0.08579645,0.0002018941,0.003520794,0.0001163861],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886346,0.004790351,0.00001113623,0.002538792,0.00006954012,0.0004262403,0.000007524149,0.00004962846,0.003472219],"genre_scores_gemma":[0.9859261,0.01259284,0.0005716152,0.0002951622,0.00001785958,0.0002738172,0.0002597673,0.00001368448,0.00004917369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0802879,"threshold_uncertainty_score":0.5154923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04094502628323648,"score_gpt":0.3261788885480821,"score_spread":0.2852338622648456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}