{"id":"W3198114585","doi":"10.1016/j.celrep.2021.109685","title":"Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; University of California, San Diego; National Institutes of Health; National University of Singapore; Paul G. Allen Frontiers Group; California Institute for Regenerative Medicine; Larry L. Hillblom Foundation; National Human Genome Research Institute; ALS Association; David and Lucile Packard Foundation; ALS Society of Canada; U.S. Department of Defense","keywords":"RNA-binding protein; Stress granule; Biology; Cell biology; Amyotrophic lateral sclerosis; RNA splicing; Subcellular localization; Neurodegeneration; RNA; Proteomics; Cytoplasm; Messenger RNA; Gene; Genetics; Translation (biology); Disease; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008549043,0.000216268,0.0002088176,0.0001427084,0.0001263896,0.0002192371,0.0001178117,0.0002238215,0.0004798385],"category_scores_gemma":[0.00008618883,0.000104471,0.0001507388,0.0001121117,0.0003352482,0.0001646495,0.0002069309,0.0003659673,0.0001358406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002126532,"about_ca_system_score_gemma":0.0001005863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003845306,"about_ca_topic_score_gemma":0.000706549,"domain_scores_codex":[0.9999055,0.000009374764,0.00001137985,0.00002760394,0.00003319591,0.00001303354],"domain_scores_gemma":[0.9999174,0.000014061,0.00003112544,0.000009978638,0.000007840999,0.00001955771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003635715,0.000005602691,0.0003035369,0.00001222788,0.000003354158,0.000102497,0.00001256884,0.00004168535,0.9990571,0.00003134281,0.0000069034,0.0003869291],"study_design_scores_gemma":[0.000006713721,0.0002550006,0.03065446,0.000006503204,0.00001671921,0.001041715,0.00009569868,0.0007572862,0.966535,0.0001739744,0.0004516219,0.000005327422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996594,0.0006973984,0.00206889,0.00002992682,0.000008782918,0.000006514331,0.0001983947,0.00004208719,0.0003540048],"genre_scores_gemma":[0.9978745,0.0003953601,0.0008900588,0.0000311387,0.000002674533,0.00001536903,0.000232748,0.00001189676,0.0005461894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004798385,"threshold_uncertainty_score":0.001605272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023795943285756,"score_gpt":0.2281173646502439,"score_spread":0.2178794052173864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}