{"id":"W3198154413","doi":"10.1161/circulationaha.121.056810","title":"Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; St. Michael's Hospital","funders":"Janssen Pharmaceuticals; American Regent; St. Jude Medical; Esperion Therapeutics; Idorsia Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Servier; Duke Clinical Research Institute; Astellas Pharma; Eisai; Cleveland Clinic; Bristol-Myers Squibb; CryoLife; Medicines Company; Regado Biosciences; Novo Nordisk; MyoKardia; Daiichi-Sankyo; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; Regeneron Pharmaceuticals; Boston VA Research Institute; Boston Scientific Corporation; Pfizer; York University; Eli Lilly and Company; CSL Behring; University of Toronto; Heart and Stroke Foundation of Canada; HLS Therapeutics; GlaxoSmithKline; Amgen; Sanofi; American Heart Association","keywords":"Medicine; Prostate cancer; Randomized controlled trial; Prostate; Cancer; Urology; Gynecology; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006769082,0.00008654238,0.0004389553,0.00003516469,0.00005029446,0.000005695036,0.00006198194,0.00004300207,0.000004375387],"category_scores_gemma":[0.00030023,0.00004139049,0.0002005761,0.000364974,0.0001628038,0.00005291714,0.00003170402,0.0001204243,3.068967e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250794,"about_ca_system_score_gemma":0.0006920177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002552772,"about_ca_topic_score_gemma":0.00004468324,"domain_scores_codex":[0.9984401,0.0002897596,0.0003695209,0.0001866907,0.000581385,0.0001325807],"domain_scores_gemma":[0.9988497,0.00016542,0.0001664041,0.0004114804,0.0003840071,0.00002299492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9235722,0.0001460777,0.0664052,0.0001181192,0.0005418076,0.00000249699,0.000697078,0.002258379,0.0001235716,0.00001299867,0.00001313332,0.006108865],"study_design_scores_gemma":[0.6369923,0.00009905952,0.3610134,0.0001898076,0.0002509643,3.523328e-7,0.00003316507,0.00009185253,0.001138901,0.00001541218,0.0001380119,0.00003687194],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925033,0.002165807,0.00001489874,0.0004706162,0.0001769646,0.00378051,0.00003856877,0.000005662745,0.0008436666],"genre_scores_gemma":[0.9992144,0.0003061108,0.00002753951,0.0000123445,0.0000408855,0.0001705249,0.0001378086,0.000009771665,0.00008063456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2946081,"threshold_uncertainty_score":0.1687855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695433379412681,"score_gpt":0.2626105683141965,"score_spread":0.2456562345200697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}