{"id":"W3198172744","doi":"10.3310/hta25530","title":"Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop","year":2021,"lang":"en","type":"article","venue":"Health Technology Assessment","topic":"Pain Management and Placebo Effect","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"Evidence Synthesis Programme; National Health and Medical Research Council; H. Lundbeck A/S; Medical Research Council; RTI International; Versus Arthritis; National Research Foundation of Korea; Health Technology Assessment Programme; European Commission; Guarantors of Brain; Department of Health and Social Care; National Institute for Health and Care Research; Elizabeth Blackwell Institute for Health Research, University of Bristol; National Research Foundation; Engineering and Physical Sciences Research Council; Eli Lilly and Company; UK Research and Innovation; Wellcome Trust","keywords":"Medicine; Placebo; Selection (genetic algorithm); Medical physics; Alternative medicine; Artificial intelligence; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008458361,0.0001912526,0.0004985095,0.0003507764,0.0004871332,0.0001129369,0.0001953537,0.0001900984,0.00002188875],"category_scores_gemma":[0.002406846,0.0001426061,0.00004836603,0.001397488,0.0001213154,0.0001754451,0.000243235,0.000714204,0.000004503012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606189,"about_ca_system_score_gemma":0.0002412438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007071312,"about_ca_topic_score_gemma":0.0005620929,"domain_scores_codex":[0.9924769,0.005616712,0.0005462556,0.0006069459,0.0002511431,0.000502025],"domain_scores_gemma":[0.9936461,0.005766842,0.0002314889,0.0002872834,0.00002036362,0.0000479358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001561072,0.002027021,0.2607712,0.0006066795,0.0001458793,0.001392814,0.001618828,0.0002224078,0.03367936,0.2902179,0.04223062,0.3655262],"study_design_scores_gemma":[0.01387456,0.001222273,0.02625179,0.0009932216,0.00006242186,0.0009216588,0.00744143,0.142366,0.01773138,0.003117661,0.7845242,0.00149334],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392259,0.002469194,0.009991167,0.04211707,0.0006613864,0.004130823,0.000007144226,0.0006734866,0.0007238662],"genre_scores_gemma":[0.9952442,0.001139234,0.001494215,0.001390178,0.00005600103,0.0005258309,0.000005396774,0.00001527213,0.0001296573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7422936,"threshold_uncertainty_score":0.5815308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2394333300880762,"score_gpt":0.4693045958024079,"score_spread":0.2298712657143317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}