{"id":"W3198174135","doi":"10.1038/s41467-021-25492-9","title":"Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut Universitaire de Gériatrie de Montréal; St Joseph's Health Centre; McGill University Health Centre; University of British Columbia Hospital; Sunnybrook Health Science Centre; McGill University; Douglas Mental Health University Institute; St Joseph's Health Care; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; Genentech; National Institutes of Health; Fleni; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Canada Research Chairs; Government of Canada; Réseau en Bio-Imagerie du Quebec; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; McGill University; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer Society; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Context (archaeology); Brain aging; Neuroscience; Disease; Alzheimer's disease; Resting state fMRI; Functional connectivity; Medicine; Neuroimaging; Psychology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0004107941,0.0001609382,0.0002039484,0.0001180129,0.0004970022,0.00006994372,0.0007046281,0.0001831367,0.0001068758],"category_scores_gemma":[0.0301184,0.0001717632,0.0001293,0.0009652169,0.000304714,0.0002645873,0.0008597163,0.001638719,0.00007443029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007098239,"about_ca_system_score_gemma":0.0003835704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001820994,"about_ca_topic_score_gemma":0.0008490824,"domain_scores_codex":[0.9975027,0.0009749647,0.0003818265,0.000565924,0.0003335449,0.0002410698],"domain_scores_gemma":[0.983556,0.01449819,0.00009253986,0.001524846,0.0002057884,0.0001225803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0005876675,0.004891647,0.3497584,0.00003455982,0.0002560977,0.0002069167,0.001032712,0.001140475,0.03894126,0.1589487,0.4295534,0.01464818],"study_design_scores_gemma":[0.0007911706,0.00001977833,0.8286826,0.00003338982,0.00003771679,0.0000135531,0.00006798534,0.002800788,0.001750466,0.001835947,0.1637075,0.00025906],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.3660194,0.02561445,0.0002604235,0.5867244,0.003964806,0.001046757,0.0002936409,0.0006216949,0.01545445],"genre_scores_gemma":[0.9754792,0.0004861221,0.000527904,0.0225068,0.0001725247,0.00009023226,0.00009441026,0.00002035373,0.0006224048],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6094598,"threshold_uncertainty_score":0.9780513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1735003038222537,"score_gpt":0.4018545961453271,"score_spread":0.2283542923230734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}