{"id":"W3198174135","doi":"10.1038/s41467-021-25492-9","title":"Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut Universitaire de Gériatrie de Montréal; St Joseph's Health Centre; McGill University Health Centre; University of British Columbia Hospital; Sunnybrook Health Science Centre; McGill University; Douglas Mental Health University Institute; St Joseph's Health Care; Montreal Neurological Institute and Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Pfizer Canada; Genentech; National Institutes of Health; Fleni; IXICO; Servier; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Canada Research Chairs; Government of Canada; Réseau en Bio-Imagerie du Quebec; Korea Health Industry Development Institute; Northern California Institute for Research and Education; Japan Agency for Medical Research and Development; McGill University; Fondation Brain Canada; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer Society; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Context (archaeology); Brain aging; Neuroscience; Disease; Alzheimer's disease; Resting state fMRI; Functional connectivity; Medicine; Neuroimaging; Psychology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004641325,0.0002762637,0.0001780102,0.0005433785,0.0001771415,0.0002236834,0.0001461265,0.0002484586,0.0004949024],"category_scores_gemma":[0.002027596,0.000130586,0.0001534538,0.0002283904,0.0002554963,0.0003259497,0.0001524488,0.0002186799,0.00005986515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423939,"about_ca_system_score_gemma":0.0001551931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003158019,"about_ca_topic_score_gemma":0.006453295,"domain_scores_codex":[0.9999388,0.00002328461,0.000003702281,0.00001903322,0.000007489441,0.000007632708],"domain_scores_gemma":[0.9995437,0.0002066188,0.0001491099,0.00004238238,0.00002642388,0.00003173949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008245668,0.0002164326,0.9176563,0.00008462604,0.0002249728,0.001166813,0.000729814,0.02765098,0.01886314,0.003542446,0.0006252041,0.02841471],"study_design_scores_gemma":[0.0000105213,0.0002086306,0.9495322,0.00001119932,0.0000385775,0.0009705703,0.0001316497,0.04036091,0.001289562,0.007159731,0.0002746514,0.00001185549],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99817,0.00008556881,0.001399925,0.00003381781,0.000001493941,0.000003145723,0.00007123754,0.00001025312,0.0002244032],"genre_scores_gemma":[0.9995,0.00004463429,0.0003524335,0.0000040579,0.000001638794,0.000002065603,0.00006346183,9.728154e-7,0.00003067166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003158019,"threshold_uncertainty_score":0.00627929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1735003038222537,"score_gpt":0.4018545961453271,"score_spread":0.2283542923230734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}