{"id":"W3198188652","doi":"10.1038/s41422-021-00558-x","title":"Mechanical activation of spike fosters SARS-CoV-2 viral infection","year":2021,"lang":"en","type":"article","venue":"Cell Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; NYU Grossman School of Medicine; Office of Science; York University; National Natural Science Foundation of China; Chinese Academy of Sciences; Westlake University; Zhejiang University; Baidu; Shandong University","keywords":"Spike (software development); Biology; Protein subunit; Receptor; Lipid bilayer fusion; Biophysics; Viral entry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Infectivity; Cell biology; Antibody; Coronavirus disease 2019 (COVID-19); Virology; Virus; Viral replication; Immunology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402598,0.0001283704,0.000283927,0.0004468503,0.000121993,0.00004912984,0.0001543455,0.0002148214,0.0000444081],"category_scores_gemma":[0.0009215393,0.0001203145,0.0001510192,0.001115273,0.0001703439,0.000144165,0.0002799693,0.0008691974,0.0002292115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829864,"about_ca_system_score_gemma":0.0008602396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983904,"about_ca_topic_score_gemma":0.0000507661,"domain_scores_codex":[0.9969226,0.0003481889,0.0003080455,0.0004393135,0.001413275,0.0005685862],"domain_scores_gemma":[0.9979639,0.0003798364,0.00004682203,0.0005596016,0.001001211,0.00004862598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004436305,0.0004107396,0.00408558,0.0003305934,0.0000296182,0.00008574609,0.0001271217,1.846872e-7,0.9829507,0.0003627682,0.001663932,0.009509401],"study_design_scores_gemma":[0.001319533,0.0004606048,0.001865593,0.00009959546,0.00001273124,0.00001741858,0.0001223034,0.0004089036,0.9569408,0.0006697469,0.03798961,0.00009315222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9742993,0.0001133213,0.0005512561,0.0005751573,0.0001091961,0.0004209523,0.000002360592,0.0000391872,0.02388931],"genre_scores_gemma":[0.9967968,0.00002351281,0.0001646898,0.002453087,0.0001921083,0.00004297998,0.00001060442,0.00003253821,0.0002836685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03632567,"threshold_uncertainty_score":0.4906282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1416143812384765,"score_gpt":0.4334143423963115,"score_spread":0.291799961157835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}