{"id":"W3198188652","doi":"10.1038/s41422-021-00558-x","title":"Mechanical activation of spike fosters SARS-CoV-2 viral infection","year":2021,"lang":"en","type":"article","venue":"Cell Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; NYU Grossman School of Medicine; Office of Science; York University; National Natural Science Foundation of China; Chinese Academy of Sciences; Westlake University; Zhejiang University; Baidu; Shandong University","keywords":"Spike (software development); Biology; Protein subunit; Receptor; Lipid bilayer fusion; Biophysics; Viral entry; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Infectivity; Cell biology; Antibody; Coronavirus disease 2019 (COVID-19); Virology; Virus; Viral replication; Immunology; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008886254,0.0001888335,0.0001423196,0.0001026877,0.0001735327,0.0001676753,0.0001009441,0.0002149215,0.001994527],"category_scores_gemma":[0.0001296632,0.0001026772,0.0001830659,0.00005394119,0.0001363194,0.0001252459,0.0002222451,0.0002917662,0.0002215545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230277,"about_ca_system_score_gemma":0.0001091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005925552,"about_ca_topic_score_gemma":0.0007523148,"domain_scores_codex":[0.9998882,0.00001257047,0.000004629299,0.00001349562,0.0000325243,0.00004853728],"domain_scores_gemma":[0.9999416,0.000009598992,0.00001346273,0.000004513831,0.0000119001,0.00001885662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007410449,0.00002348217,0.0005058157,0.00001842956,0.00000258581,0.00004646429,0.0000107892,0.00006552652,0.9985412,0.00005955571,0.00005921725,0.0005927667],"study_design_scores_gemma":[0.00001932638,0.000969765,0.04061332,0.00001094642,0.00001134777,0.0003373506,0.0001555142,0.006247284,0.9494817,0.0001274758,0.002014844,0.00001114597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998392,0.0003069485,0.0003641358,0.00005508976,0.00001826375,0.000009404635,0.00004374698,0.00001139351,0.0007989847],"genre_scores_gemma":[0.9990846,0.000105728,0.0002037627,0.00003416272,0.000007234403,0.000008455568,0.00006018952,0.000002091487,0.0004938472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001994527,"threshold_uncertainty_score":0.006672323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1416143812384765,"score_gpt":0.4334143423963115,"score_spread":0.291799961157835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}