{"id":"W3198218354","doi":"10.1101/2021.03.26.437132","title":"Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Division of Molecular and Cellular Biosciences; National Institutes of Health; National Science Foundation","keywords":"EPH receptor A2; Cell biology; Ephrin; Biology; Receptor; Viral entry; Viral envelope; Endosome; Glycoprotein; Herpesvirus glycoprotein B; Signal transduction; Molecular mimicry; Erythropoietin-producing hepatocellular (Eph) receptor; Receptor tyrosine kinase; Biochemistry; Virus; Viral replication; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007397692,0.0001425433,0.00009900609,0.00007281197,0.00009819178,0.0001848367,0.0001020126,0.0001755401,0.002067237],"category_scores_gemma":[0.00009477453,0.00005617495,0.0001042921,0.00004953848,0.0001393011,0.0001401136,0.0002079896,0.0002861848,0.0004334755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240489,"about_ca_system_score_gemma":0.0001167471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004874574,"about_ca_topic_score_gemma":0.0005932918,"domain_scores_codex":[0.9999278,0.00001330555,0.000002881342,0.00001221488,0.00002240607,0.00002143654],"domain_scores_gemma":[0.9999769,0.000006119451,0.000004394931,0.000003565957,0.000002492962,0.000006472952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007174251,0.00001458137,0.0001579572,0.0000154491,0.00000266752,0.0000679479,0.00001136296,0.000128097,0.9981183,0.0005540411,0.0001402113,0.0007177673],"study_design_scores_gemma":[0.00001474631,0.00006390715,0.001824986,0.000003521903,0.00000242058,0.0001454923,0.00002700425,0.003902403,0.9919,0.000185933,0.001926905,0.000002740298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952214,0.0002282808,0.001757505,0.0000938592,0.00001756045,0.000007985864,0.00009345574,0.00004522527,0.00253458],"genre_scores_gemma":[0.9960748,0.0001244069,0.001408618,0.00003164291,0.000004197147,0.00000741108,0.0001231437,0.00001276489,0.002213086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002067237,"threshold_uncertainty_score":0.006915629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193023128060389,"score_gpt":0.2306015063992788,"score_spread":0.2112991935932398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}