{"id":"W3198245921","doi":"10.1016/j.celrep.2021.109546","title":"PSMB11 regulates gene expression in cortical thymic epithelial cells","year":2021,"lang":"en","type":"letter","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Cole Foundation","keywords":"Biology; Major histocompatibility complex; Cell biology; Transcriptome; CD8; Transcription factor; Gene expression; Gene; Antigen presentation; Protein subunit; T cell; Immunology; Antigen; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00024945,0.0002445091,0.0001599676,0.0002704846,0.0002658133,0.000544046,0.0001836968,0.001073116,0.001067483],"category_scores_gemma":[0.0004624673,0.00009863961,0.0001534819,0.0001952492,0.0004140291,0.0002352136,0.0002065664,0.001136539,0.001100636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005757989,"about_ca_system_score_gemma":0.0001599136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003661877,"about_ca_topic_score_gemma":0.000666178,"domain_scores_codex":[0.9997466,0.00003439258,0.00001476379,0.00005311325,0.0001016652,0.00004948396],"domain_scores_gemma":[0.9997182,0.00009086334,0.00003676978,0.00002858401,0.00006712526,0.00005833985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009204735,0.00005933575,0.007757051,0.0004131258,0.00003168586,0.01096994,0.0001960291,0.0002325586,0.8490657,0.002815381,0.0611253,0.06641354],"study_design_scores_gemma":[0.0001165565,0.0004332032,0.07390328,0.0001038467,0.00005061558,0.01690497,0.0005772442,0.001818292,0.3884583,0.004168245,0.5134158,0.00004971836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.631465,0.1065734,0.01065998,0.1727678,0.02199409,0.0001939059,0.002450694,0.001332815,0.05256232],"genre_scores_gemma":[0.8775449,0.02784854,0.00262951,0.0436231,0.009468657,0.000111731,0.001061701,0.0001209665,0.03759079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073116,"threshold_uncertainty_score":0.00417769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161079069710021,"score_gpt":0.2218575753737999,"score_spread":0.2102467846766997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}