{"id":"W3198246574","doi":"10.1016/j.pharmthera.2021.107977","title":"G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)","year":2021,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Fundación Dr. Antoni Esteve; National Institute of General Medical Sciences; National Institute of Mental Health; Centre National de la Recherche Scientifique; Universitat de Barcelona; National Institute on Drug Abuse; Agencia Estatal de Investigación; Ministerio de Ciencia, Innovación y Universidades; Agence Nationale de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"G protein-coupled receptor; Effector; Heterotrimeric G protein; Cell biology; Biology; Receptor; Rhodopsin-like receptors; G protein; Cell signaling; Signal transduction; Chemistry; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005614446,0.0009844336,0.001905937,0.0001610031,0.0002187917,0.00009927056,0.0008010053,0.001196922,0.001734959],"category_scores_gemma":[0.00001636784,0.0008871314,0.001104539,0.0003517362,0.0001433124,0.000006728815,0.000360729,0.0007701594,0.0001851561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008677871,"about_ca_system_score_gemma":0.0006155821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000567681,"about_ca_topic_score_gemma":0.000002049019,"domain_scores_codex":[0.9958556,0.001018824,0.0008111757,0.001169718,0.0003257743,0.0008189055],"domain_scores_gemma":[0.9982804,0.00008382028,0.0005184689,0.0006807494,0.0002316743,0.0002048954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003671554,0.0001753312,3.309678e-7,0.002434526,0.003255993,0.00005815363,0.00001912585,0.000004895933,0.8575451,0.00004373723,0.001133439,0.1352927],"study_design_scores_gemma":[0.0004571037,0.0002227391,2.450054e-8,0.0007068207,0.002178724,0.00006133859,0.000009483405,0.00002066969,0.2547461,0.000005466753,0.7409263,0.0006652251],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001184529,0.9936483,0.001088912,0.00007618133,0.001855105,0.00181539,0.0001086166,0.00007008646,0.0001528852],"genre_scores_gemma":[0.0001405697,0.9921296,0.001045598,0.001130286,0.001398527,0.0007649995,0.001695037,0.0002665799,0.001428779],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7397929,"threshold_uncertainty_score":0.9993579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04711255134344652,"score_gpt":0.3494191150187398,"score_spread":0.3023065636752933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}