{"id":"W3198246574","doi":"10.1016/j.pharmthera.2021.107977","title":"G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs)","year":2021,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Fundación Dr. Antoni Esteve; National Institute of General Medical Sciences; National Institute of Mental Health; Centre National de la Recherche Scientifique; Universitat de Barcelona; National Institute on Drug Abuse; Agencia Estatal de Investigación; Ministerio de Ciencia, Innovación y Universidades; Agence Nationale de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"G protein-coupled receptor; Effector; Heterotrimeric G protein; Cell biology; Biology; Receptor; Rhodopsin-like receptors; G protein; Cell signaling; Signal transduction; Chemistry; Biochemistry; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003649439,0.001106915,0.001033322,0.001886808,0.0003110766,0.0009808718,0.0009965289,0.001156523,0.002828699],"category_scores_gemma":[0.0003373252,0.0002778958,0.0002973038,0.001720753,0.0006323209,0.00162494,0.000905834,0.001672911,0.00410533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007668531,"about_ca_system_score_gemma":0.0006074388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006883902,"about_ca_topic_score_gemma":0.001148852,"domain_scores_codex":[0.9998924,0.00001712682,0.000009560761,0.00002470789,0.00004051872,0.00001573397],"domain_scores_gemma":[0.9999002,0.0000334514,0.00001811676,0.000006542079,0.0000248685,0.00001670492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006661865,0.00008217742,0.0001204309,0.009067349,0.00004598627,0.0002783592,0.00006207386,0.0005452423,0.007478752,0.02236575,0.03640836,0.9234789],"study_design_scores_gemma":[0.000006512525,0.0000388658,0.0001610589,0.0004780336,0.00002032378,0.0005549755,0.00001667553,0.00006218934,0.0011443,0.00149201,0.9960157,0.000009333221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002382625,0.9960697,0.0004326427,0.0001963073,0.000276408,0.000008674787,0.00002884278,0.00002645531,0.002722796],"genre_scores_gemma":[0.002126481,0.9942958,0.0006601809,0.0002134386,0.0001497621,0.00001683882,0.00008192693,0.000004567225,0.002451039],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002828699,"threshold_uncertainty_score":0.009462893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04711255134344652,"score_gpt":0.3494191150187398,"score_spread":0.3023065636752933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}