{"id":"W3198256784","doi":"10.1152/ajpgi.00221.2021","title":"Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Calgary","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Autophagy; Mucin; Cell biology; Mucin 2; Endoplasmic reticulum; Homeostasis; Unfolded protein response; Biology; Biosynthesis; Chemistry; Biochemistry; Enzyme; Gene; Gene expression; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473379,0.0001581617,0.0003818208,0.0001916245,0.0002998509,0.0005202211,0.00008320672,0.0003416751,0.001299885],"category_scores_gemma":[0.0001468924,0.0001323886,0.0003335932,0.0001531046,0.0002854243,0.000285826,0.0003256475,0.0005295663,0.0003292971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003346258,"about_ca_system_score_gemma":0.0002607012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000642251,"about_ca_topic_score_gemma":0.001167557,"domain_scores_codex":[0.9998155,0.00002896412,0.00001797576,0.00003475899,0.00002975945,0.00007300776],"domain_scores_gemma":[0.9998655,0.000008650402,0.00003310085,0.00001399752,0.000017057,0.00006165446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000510842,0.00001875339,0.00206986,0.00007475846,0.000008096553,0.0003076172,0.00004292174,0.00004618852,0.9959241,0.0001498748,0.0001422709,0.0007047263],"study_design_scores_gemma":[0.0001089454,0.0006177982,0.2328468,0.00007803772,0.00006457774,0.001871263,0.0009455699,0.002913091,0.7514484,0.0004807799,0.008585889,0.00003880009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963036,0.001821267,0.000577546,0.0001999979,0.00004821274,0.00001186264,0.0003144069,0.0000370893,0.0006859493],"genre_scores_gemma":[0.9982123,0.0002991923,0.0003254536,0.00008421966,0.000009329252,0.00001905096,0.0003116833,0.000006927326,0.0007319849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299885,"threshold_uncertainty_score":0.004348576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008126793828725144,"score_gpt":0.2396091835657422,"score_spread":0.2314823897370171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}