{"id":"W3198276706","doi":"10.1200/po.21.00112","title":"Long-Term Report of a Comprehensive Molecular and Genomic Analysis in NRG Oncology/RTOG 0424: A Phase II Study of Radiation and Temozolomide in High-Risk Grade II Glioma","year":2021,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Cancer Care Ontario","funders":"National Cancer Institute; NRG Oncology; Ohio State University; Pennsylvania Department of Health","keywords":"Methylation; Temozolomide; Oncology; Hazard ratio; Internal medicine; Glioma; ATRX; Proportional hazards model; Medicine; Progression-free survival; Radiation therapy; Cancer research; Biology; Gene; Overall survival; Genetics; Confidence interval; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004914436,0.0002057985,0.001459621,0.00106128,0.00005981922,0.000005315239,0.0000652925,0.0002471905,0.00003894732],"category_scores_gemma":[0.0002877079,0.0001838691,0.0001187138,0.001034503,0.0001079523,0.00004982218,0.0002755827,0.0002043243,5.501933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493842,"about_ca_system_score_gemma":0.0002349482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008613452,"about_ca_topic_score_gemma":0.002884308,"domain_scores_codex":[0.9972643,0.0005478752,0.00111738,0.0006153634,0.0002397777,0.0002152971],"domain_scores_gemma":[0.9979626,0.0006065411,0.0006652957,0.0004572939,0.0001829235,0.0001253371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001210376,0.01710431,0.7850017,0.00003601907,0.001182037,0.01859123,0.002792859,0.0002803626,0.08953589,0.00001354113,0.00003147794,0.08422022],"study_design_scores_gemma":[0.03091118,0.01319413,0.9294699,0.0000587124,0.001894831,0.000625131,0.0008172044,0.0003323791,0.02236876,0.00009271193,0.0001103364,0.0001246645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955855,0.00269097,0.00002760461,0.0004852954,0.00008396812,0.001066289,0.00002087101,0.000008772114,0.00003070418],"genre_scores_gemma":[0.9984556,0.0006479935,0.0006079592,0.00005577669,0.00001628685,0.0001054783,0.00008748302,0.00001455807,0.000008841887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1444683,"threshold_uncertainty_score":0.7497963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258978242713206,"score_gpt":0.3559463888212738,"score_spread":0.3333566063941417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}