{"id":"W3198276706","doi":"10.1200/po.21.00112","title":"Long-Term Report of a Comprehensive Molecular and Genomic Analysis in NRG Oncology/RTOG 0424: A Phase II Study of Radiation and Temozolomide in High-Risk Grade II Glioma","year":2021,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Cancer Care Ontario","funders":"National Cancer Institute; NRG Oncology; Ohio State University; Pennsylvania Department of Health","keywords":"Methylation; Temozolomide; Oncology; Hazard ratio; Internal medicine; Glioma; ATRX; Proportional hazards model; Medicine; Progression-free survival; Radiation therapy; Cancer research; Biology; Gene; Overall survival; Genetics; Confidence interval; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002208901,0.0004586848,0.0008423614,0.0002295689,0.0002913226,0.0005604217,0.0003870717,0.0003017951,0.0005270171],"category_scores_gemma":[0.001169369,0.0002388633,0.0004223188,0.0002533563,0.0003394819,0.0002815795,0.000234657,0.0005350905,0.0002717423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000673591,"about_ca_system_score_gemma":0.0006593208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384832,"about_ca_topic_score_gemma":0.003006811,"domain_scores_codex":[0.999447,0.0002511747,0.00003302754,0.00009435602,0.0001072146,0.00006713226],"domain_scores_gemma":[0.9992174,0.00009666272,0.0002315031,0.0001229858,0.00007875489,0.0002525992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04100345,0.008277167,0.5425543,0.0003955443,0.002629366,0.001161965,0.0005336885,0.002877908,0.1885294,0.0001307874,0.004876731,0.2070296],"study_design_scores_gemma":[0.006695121,0.1045016,0.8358158,0.00004031846,0.00238974,0.003432007,0.0002816272,0.002233315,0.03143872,0.0001870768,0.01292489,0.00005962127],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971079,0.001302188,0.0004184105,0.0001495967,0.00001397185,0.00008680927,0.0005144513,0.00002738871,0.0003791875],"genre_scores_gemma":[0.9954081,0.0007060072,0.0008484464,0.0002388178,0.0000354304,0.0001061271,0.00181587,0.00001906816,0.0008221414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208901,"threshold_uncertainty_score":0.01168191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258978242713206,"score_gpt":0.3559463888212738,"score_spread":0.3333566063941417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}