{"id":"W3198293176","doi":"10.1139/bcb-2021-0017","title":"Aberrant mTOR/autophagy/Nurr1 signaling is critical for TSC-associated tumor development","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"TSC1; TSC2; PI3K/AKT/mTOR pathway; Autophagy; Carcinogenesis; Cancer research; Biology; Nuclear receptor; Tuberous sclerosis; Cell growth; Mechanistic target of rapamycin; Cell biology; Signal transduction; Cancer; Pathology; Medicine; Gene; Genetics; Transcription factor; Apoptosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404382,0.0001532467,0.0002020293,0.00001479713,0.0002628537,0.00004425132,0.000114939,0.0001597692,0.0004656908],"category_scores_gemma":[0.00040148,0.0001452556,0.00006849113,0.00008477813,0.000134864,0.00002245565,0.00007575303,0.0001251384,0.00001661746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002986319,"about_ca_system_score_gemma":0.0001169707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001574457,"about_ca_topic_score_gemma":1.780438e-7,"domain_scores_codex":[0.9987608,0.00005235432,0.0002361253,0.0005225802,0.00007142121,0.0003567358],"domain_scores_gemma":[0.999348,0.0002980492,0.00005807504,0.0001147674,0.00006335712,0.0001177597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000204092,0.00009198677,0.00008174172,0.00006960125,0.000005492381,0.00001641873,0.0001037216,2.954072e-7,0.9982862,0.0002413877,0.0003641854,0.000718572],"study_design_scores_gemma":[0.0003619355,0.00004076942,0.00001356415,0.00002578517,0.00001097808,0.00001636636,0.0001103604,0.0001224135,0.9766819,0.0002261609,0.02219557,0.0001941915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968544,0.000651755,0.000180231,0.0002304167,0.0001990803,0.00007104088,0.00004515823,0.00004374615,0.001724159],"genre_scores_gemma":[0.9965967,0.00002654792,0.0008265326,0.00117222,0.0001068909,0.00001518562,0.00002575374,0.00001517544,0.001215016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02183139,"threshold_uncertainty_score":0.5923351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02522569442898853,"score_gpt":0.2666978686902866,"score_spread":0.241472174261298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}