{"id":"W3198295695","doi":"10.1371/journal.pgen.1009774","title":"A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; Simons Foundation Autism Research Initiative","keywords":"PTEN; Biology; Computational biology; PI3K/AKT/mTOR pathway; Drosophila melanogaster; Function (biology); Genetics; Gene; Protein kinase B; Genetic screen; Mutant; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001816003,0.001031347,0.0005380682,0.00112536,0.0006520625,0.0007589314,0.0008229629,0.000965782,0.002537671],"category_scores_gemma":[0.001424612,0.0005586396,0.0006369745,0.0004658838,0.0005221295,0.0003363437,0.0009077067,0.001303278,0.001407838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000797249,"about_ca_system_score_gemma":0.0005206873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001962509,"about_ca_topic_score_gemma":0.005219474,"domain_scores_codex":[0.9980589,0.0004835448,0.0002103188,0.000422385,0.0007036703,0.0001211946],"domain_scores_gemma":[0.9990076,0.0003192284,0.0001563767,0.0002133805,0.0002073534,0.00009607049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007943033,0.00005841708,0.002155849,0.0000896475,0.00003168717,0.00009023858,0.00008061373,0.0004515974,0.9907823,0.0004706538,0.0006425383,0.005067077],"study_design_scores_gemma":[0.00004045553,0.0006024064,0.009202203,0.00003532493,0.00008690409,0.0004820759,0.00007424232,0.00702673,0.9726424,0.0003697697,0.009384411,0.00005299604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6290467,0.002336392,0.3273458,0.001005261,0.0003685762,0.003171853,0.01550619,0.006525622,0.01469354],"genre_scores_gemma":[0.6069835,0.001735248,0.3648873,0.0006466341,0.00004708878,0.002876658,0.01286323,0.000539673,0.00942065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002537671,"threshold_uncertainty_score":0.009604037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05091783683673328,"score_gpt":0.3437822030544226,"score_spread":0.2928643662176894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}