{"id":"W3198297627","doi":"10.21203/rs.3.rs-649284/v1","title":"Altered RNA splicing initiates the viral mimicry response from inverted SINEs following type I PRMT inhibition in Triple-Negative Breast Cancer","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Princess Margaret Cancer Centre; Institute for Research in Immunology and Cancer; University of Toronto; University Health Network; Structural Genomics Consortium","funders":"Terry Fox Research Institute; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Institute for Cancer Research; Princess Margaret Cancer Foundation; Government of Ontario; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Triple-negative breast cancer; Mimicry; RNA splicing; Biology; Breast cancer; Alternative splicing; RNA; Cancer; Genetics; Gene; Messenger RNA; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036951,0.0001491291,0.0001839585,0.0001265876,0.00007283593,0.0001777238,0.0001025598,0.0001889084,0.001873402],"category_scores_gemma":[0.0001012092,0.00006863146,0.000160857,0.00008377485,0.0001144889,0.00007011124,0.0001053356,0.0002731565,0.0004073424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001602803,"about_ca_system_score_gemma":0.000105647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003095035,"about_ca_topic_score_gemma":0.0003884335,"domain_scores_codex":[0.9999332,0.0000103115,0.000003864227,0.0000145761,0.00002412722,0.00001398365],"domain_scores_gemma":[0.9999636,0.000009447363,0.00001005287,0.000004206263,0.00000493035,0.000007801887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007912281,0.000008862707,0.0002126208,0.00001235035,0.000002127186,0.00003779019,0.000003995412,0.00006840674,0.9985373,0.00005343815,0.00003622896,0.0009477064],"study_design_scores_gemma":[0.000008329228,0.0001995826,0.002967827,0.000001793464,0.000004425054,0.0001608064,0.00001209779,0.001208827,0.9942754,0.0000624551,0.001097013,0.00000150884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919011,0.001228557,0.003433289,0.0001064788,0.00004653311,0.00002396068,0.0004479266,0.0001129421,0.002699096],"genre_scores_gemma":[0.9938368,0.0004258084,0.002119279,0.00005826767,0.000008333514,0.00001551827,0.0005058926,0.00002355026,0.003006558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001873402,"threshold_uncertainty_score":0.00626713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03856941729648836,"score_gpt":0.3640304660046741,"score_spread":0.3254610487081858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}