{"id":"W3198333183","doi":"10.3390/cells10092270","title":"Glycogen Synthase Kinase-3: A Focal Point for Advancing Pathogenic Inflammation in Depression","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"GSK-3; Inflammation; Neuropathology; Neuroscience; Microglia; Depression (economics); Biology; Signal transduction; Glycogen synthase; Medicine; Bioinformatics; Immunology; Disease; Cell biology; Internal medicine; Glycogen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003468042,0.0003098634,0.0006335827,0.00008449791,0.00005217591,0.00002974163,0.0002130378,0.0004353977,0.00004661332],"category_scores_gemma":[0.0001126224,0.0002843203,0.0003694077,0.0001325381,0.00002131231,0.000004243714,0.0001468627,0.0001400299,0.00001461867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008426893,"about_ca_system_score_gemma":0.0004395696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002810754,"about_ca_topic_score_gemma":0.00001203851,"domain_scores_codex":[0.9983925,0.0001006459,0.0005084806,0.0005547829,0.0001194782,0.0003240682],"domain_scores_gemma":[0.9992498,0.0000537515,0.000221883,0.0003262799,0.00007452005,0.00007377223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002594577,0.00003160741,0.000005366416,0.003704555,0.00007795211,0.00002505592,0.00002478386,0.00003728244,0.08684469,0.000005459725,0.001947708,0.9072696],"study_design_scores_gemma":[0.0003080324,0.00003807759,5.248559e-7,0.004250026,0.0001350598,0.0000108802,0.00001324208,0.00001263885,0.1016716,0.00001737599,0.8931904,0.0003521014],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000848921,0.9957047,0.002093714,0.000005548402,0.0003875302,0.0007564324,0.00004853181,0.00001056813,0.0001441105],"genre_scores_gemma":[0.0002867591,0.9943627,0.002138937,0.00003110136,0.0004724729,0.0005470795,0.001549469,0.0000662364,0.0005452415],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9069175,"threshold_uncertainty_score":0.9999609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823328389421269,"score_gpt":0.2976847241392475,"score_spread":0.2794514402450348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}