{"id":"W3198359021","doi":"10.3390/biomedicines9091186","title":"Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Public Health Agency of Canada; University of Guelph","funders":"Mitacs","keywords":"Monoclonal antibody; Tolerability; Antibody; Virology; Virus; Vector (molecular biology); Vaccination; Immunology; Biology; Immunity; Medicine; Pharmacology; Adverse effect; Immune system; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006947056,0.0003396442,0.0004977735,0.0002644425,0.0001488179,0.0004834558,0.0002300145,0.0004569516,0.001170182],"category_scores_gemma":[0.000723829,0.0001165951,0.0003212714,0.0001290064,0.0003935564,0.0004442917,0.0001283286,0.0007447196,0.0002684846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717356,"about_ca_system_score_gemma":0.000266562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005437881,"about_ca_topic_score_gemma":0.0007144565,"domain_scores_codex":[0.9995769,0.000115196,0.00002977182,0.00009626614,0.0001346427,0.00004720328],"domain_scores_gemma":[0.9994641,0.0001037161,0.0002029588,0.00007222579,0.00009731591,0.00005973339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003030967,0.0006491296,0.001919985,0.0002216576,0.00004006574,0.0002402862,0.0001822358,0.0004424776,0.973457,0.0001663579,0.0003881109,0.0192618],"study_design_scores_gemma":[0.0002412993,0.08897943,0.02696716,0.00009956056,0.000282016,0.001856769,0.0002677285,0.002598639,0.8663017,0.0002836078,0.01206653,0.00005557277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867512,0.002578102,0.007612328,0.0002239623,0.00007873459,0.0001914913,0.0006287071,0.00016805,0.001767339],"genre_scores_gemma":[0.9909802,0.001791652,0.002738491,0.0001464231,0.00005458658,0.0001969448,0.000838647,0.00005594111,0.003197131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170182,"threshold_uncertainty_score":0.003914654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939788644354859,"score_gpt":0.3044292412265804,"score_spread":0.2850313547830319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}