{"id":"W3198359021","doi":"10.3390/biomedicines9091186","title":"Safety and Tolerability of the Adeno-Associated Virus Vector, AAV6.2FF, Expressing a Monoclonal Antibody in Murine and Ovine Animal Models","year":2021,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Public Health Agency of Canada; University of Guelph","funders":"Mitacs","keywords":"Monoclonal antibody; Tolerability; Antibody; Virology; Virus; Vector (molecular biology); Vaccination; Immunology; Biology; Immunity; Medicine; Pharmacology; Adverse effect; Immune system; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003678551,0.0001333802,0.0002451768,0.00004802247,0.00006501629,0.00001169619,0.0001175203,0.0001162451,0.00001723504],"category_scores_gemma":[0.0001573292,0.00009874416,0.00003984852,0.0002353328,0.0003147606,0.000006220839,0.0002253254,0.0001036637,1.405797e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001890236,"about_ca_system_score_gemma":0.0001320216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001720034,"about_ca_topic_score_gemma":0.0005422799,"domain_scores_codex":[0.9988135,0.0001714394,0.0002742628,0.0003327575,0.0001955706,0.0002125489],"domain_scores_gemma":[0.9994259,0.00003554213,0.00007519968,0.0002826633,0.0001132372,0.00006745426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00108203,0.0001157336,0.02177968,0.00004094118,0.00003904603,0.00000679977,0.0001045283,0.0000176275,0.9755647,0.000007019581,0.00004308821,0.001198779],"study_design_scores_gemma":[0.002290185,0.001065647,0.21885,0.0001238741,0.00001948995,0.00002201083,0.0001203736,0.001892901,0.774841,0.0001334522,0.0004712407,0.0001698288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914121,0.007346313,0.00004388492,0.0008729831,0.00004806722,0.0001491401,0.00005823451,0.000005327845,0.00006393356],"genre_scores_gemma":[0.9986077,0.0009599492,0.00006517821,0.0001100567,0.00008559162,0.000005014002,0.00006550748,0.00001376213,0.00008724794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2007237,"threshold_uncertainty_score":0.402667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939788644354859,"score_gpt":0.3044292412265804,"score_spread":0.2850313547830319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}