{"id":"W3198368556","doi":"10.3389/fgene.2021.711624","title":"Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis","year":2021,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Novo Nordisk Fonden; National Institute of Mental Health; Aarhus Universitet; Novo Nordisk; National Institutes of Health; H. Lundbeck A/S; Humboldt-Universität zu Berlin; Lundbeckfonden; Horizon 2020 Framework Programme; Deutsche Forschungsgemeinschaft","keywords":"Polygenic risk score; Obsessive compulsive; Comorbidity; Psychology; Psychiatry; Clinical psychology; Medicine; Genetics; Biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001916492,0.0006607951,0.0009126168,0.0001824461,0.0002763091,0.000133503,0.000848037,0.0004585608,0.000604898],"category_scores_gemma":[0.0001639271,0.0007718364,0.0003671627,0.001167173,0.0004593609,0.0001129645,0.0004063396,0.0006482914,0.0001964637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773256,"about_ca_system_score_gemma":0.0001312324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003426219,"about_ca_topic_score_gemma":0.001222653,"domain_scores_codex":[0.9951538,0.0006023736,0.0008351337,0.001393523,0.0004802261,0.001534912],"domain_scores_gemma":[0.9976474,0.0002192671,0.0003334099,0.00130406,0.0001865001,0.0003093698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009479358,0.001192056,0.9248341,0.00003071854,0.0003553659,0.0002650273,0.002291475,0.000190419,0.0002948134,0.0001459832,0.0515396,0.01876569],"study_design_scores_gemma":[0.006795193,0.0003264696,0.9281235,0.00006793844,0.0001562439,0.00006948385,0.01072821,0.0005996037,0.005053075,0.002193822,0.04425839,0.001628085],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9221099,0.05871305,0.01049951,0.0009123595,0.005389833,0.0005908612,0.0005203206,0.0001217336,0.001142431],"genre_scores_gemma":[0.9845158,0.002460131,0.00986354,0.001103522,0.0001703723,0.0003770779,0.0004484465,0.000177087,0.000883953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06240597,"threshold_uncertainty_score":0.9994733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0118824006472816,"score_gpt":0.2923192349901647,"score_spread":0.2804368343428831,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}