{"id":"W3198399789","doi":"10.1016/j.xcrm.2021.100387","title":"Levels of circulating semaglutide determine reductions in HbA1c and body weight in people with type 2 diabetes","year":2021,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; Novo Nordisk; Pfizer","keywords":"Semaglutide; Medicine; Type 2 diabetes; Nausea; Adverse effect; Diabetes mellitus; Dulaglutide; Body weight; Internal medicine; Vomiting; Pharmacodynamics; Oral administration; Pharmacology; Liraglutide; Endocrinology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004798947,0.0002376455,0.0003729817,0.0003185645,0.000103021,0.0005166124,0.0001166974,0.0004207661,0.002235775],"category_scores_gemma":[0.0009447887,0.000177913,0.0002779091,0.0003345321,0.0001576857,0.0002380771,0.0001730766,0.0006041163,0.0004522154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623414,"about_ca_system_score_gemma":0.00009929447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005474605,"about_ca_topic_score_gemma":0.001068607,"domain_scores_codex":[0.9997564,0.00007782308,0.00002093318,0.00004403105,0.00007550148,0.00002521548],"domain_scores_gemma":[0.9996502,0.0001117811,0.0001227059,0.00001846636,0.00004015677,0.00005664621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0132844,0.0009612924,0.8471594,0.0003441186,0.0007457671,0.0002924055,0.0002944816,0.0003280623,0.04268741,0.0002228921,0.002097683,0.09158209],"study_design_scores_gemma":[0.0001333609,0.002252828,0.9861171,0.0000561633,0.0003502058,0.0009936137,0.0002092114,0.0008059539,0.007602196,0.0001871282,0.001277909,0.00001430937],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927251,0.003698508,0.0004435877,0.0001552373,0.00008195595,0.00001335149,0.0002647615,0.00003263442,0.002584689],"genre_scores_gemma":[0.9971465,0.0007003791,0.0005546344,0.0001803561,0.00004163445,0.00001348768,0.0002405288,0.000008105192,0.001114395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002235775,"threshold_uncertainty_score":0.00747937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140101512350048,"score_gpt":0.244574560100199,"score_spread":0.2305644088651942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}