{"id":"W3198418011","doi":"10.1126/sciadv.abj5365","title":"Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; ZonMw; Bill and Melinda Gates Foundation","keywords":"Neutralization; Vaccination; Virology; Immunity; Antibody; Titer; Immune system; Neutralizing antibody; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Monoclonal antibody; Coronavirus disease 2019 (COVID-19); Humoral immunity; Biology; Medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003121322,0.0002386903,0.000218143,0.0001338364,0.0001484105,0.0004320786,0.0001129245,0.00025437,0.004277015],"category_scores_gemma":[0.0005800608,0.00007738305,0.0001744681,0.00007879436,0.0001303972,0.0001808706,0.0002612354,0.0003213011,0.0007720407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002218134,"about_ca_system_score_gemma":0.0001735842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021798,"about_ca_topic_score_gemma":0.001140716,"domain_scores_codex":[0.9998221,0.00003585104,0.00001129971,0.00002528862,0.00003659476,0.00006889964],"domain_scores_gemma":[0.9998509,0.00003714717,0.0000289287,0.00001826113,0.00003483957,0.00002997879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008248812,0.0005624015,0.1830329,0.0002890541,0.0001040224,0.0004427127,0.0005183663,0.0004930542,0.6910893,0.0008955499,0.00431877,0.1174289],"study_design_scores_gemma":[0.0001314312,0.005818736,0.7840255,0.0001048349,0.00009221484,0.004335497,0.0009479974,0.002022874,0.168044,0.0006158412,0.03384152,0.00001959774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992946,0.0007389915,0.0005507185,0.0001289893,0.00002868325,0.00003157073,0.0001449236,0.00004311319,0.005387053],"genre_scores_gemma":[0.9975653,0.0002535476,0.0002824377,0.00013947,0.00002030749,0.00001116795,0.0002277957,0.000003944554,0.001496052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004277015,"threshold_uncertainty_score":0.01430804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05635676759586372,"score_gpt":0.4131301950786671,"score_spread":0.3567734274828034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}