{"id":"W3198418011","doi":"10.1126/sciadv.abj5365","title":"Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; ZonMw; Bill and Melinda Gates Foundation","keywords":"Neutralization; Vaccination; Virology; Immunity; Antibody; Titer; Immune system; Neutralizing antibody; Immunology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Monoclonal antibody; Coronavirus disease 2019 (COVID-19); Humoral immunity; Biology; Medicine; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006058493,0.00008964413,0.0001990618,0.000201512,0.0001825998,0.00004745664,0.000110315,0.00003466578,0.0000143464],"category_scores_gemma":[0.001238278,0.00007947772,0.00003468487,0.0009554923,0.0003110835,0.0007698306,0.00009940001,0.0001185952,0.000008062831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007806434,"about_ca_system_score_gemma":0.0005176868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000411965,"about_ca_topic_score_gemma":0.0001219386,"domain_scores_codex":[0.9985798,0.00006433706,0.0002197502,0.0003610316,0.0005368186,0.0002382709],"domain_scores_gemma":[0.9991584,0.000156023,0.00009664218,0.0002325197,0.0003357259,0.00002067301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278855,0.00003837379,0.07906428,0.00003102614,0.000007032576,0.00001981829,0.0003658332,8.801195e-7,0.8827264,0.00008327037,0.000004296753,0.03753093],"study_design_scores_gemma":[0.0005281325,0.0001051652,0.2379524,0.00007199913,0.00001211718,0.00001671658,0.0002801565,0.000260345,0.7561326,0.0008244531,0.003751922,0.0000639549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941245,0.003855745,0.0003232874,0.0002892558,0.0002500423,0.0001261747,0.000005924216,0.00002838045,0.0009967193],"genre_scores_gemma":[0.9978742,0.00007853234,0.0006298498,0.001315009,0.00006214329,0.000007893079,0.000001766223,0.000006360833,0.00002423764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1588882,"threshold_uncertainty_score":0.3241007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05635676759586372,"score_gpt":0.4131301950786671,"score_spread":0.3567734274828034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}