{"id":"W3198441430","doi":"10.1021/acs.chemmater.1c01695","title":"Hierarchical Self-Assembly Route to “Polyplex-in-Hydrophobic-Core” Micelles for Gene Delivery","year":2021,"lang":"en","type":"article","venue":"Chemistry of Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Micelle; Ethylene glycol; Copolymer; Chemistry; Nucleic acid; Polymer; PEG ratio; Nuclease; Polymer chemistry; Materials science; Biophysics; Organic chemistry; Aqueous solution; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000963058,0.0003761988,0.0001563309,0.0002231532,0.0001329934,0.0001971221,0.0002328187,0.0002412326,0.001027687],"category_scores_gemma":[0.0000974108,0.0001861936,0.0002300726,0.0001250047,0.0001031655,0.0002273078,0.0001932366,0.0004671281,0.0009322584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000386011,"about_ca_system_score_gemma":0.0002757469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405615,"about_ca_topic_score_gemma":0.0008634527,"domain_scores_codex":[0.9999068,0.00001041185,0.000008911365,0.00002602811,0.00002453748,0.00002323761],"domain_scores_gemma":[0.9999449,0.000004341809,0.00002039334,0.000005700967,0.00001211293,0.00001242708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001015508,0.00001943953,0.00002896793,0.0000277733,0.000003205535,0.0000312249,0.00001106644,0.0002270946,0.9975936,0.00021854,0.00008898999,0.001739952],"study_design_scores_gemma":[0.0000100095,0.0001119169,0.0003590002,0.000002145546,0.000005624047,0.00007597099,0.000003715333,0.002389302,0.9942393,0.00005007288,0.002748767,0.000004307922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8905528,0.002179557,0.09483417,0.0004365898,0.0001153956,0.0005570999,0.0007485953,0.00187636,0.008699507],"genre_scores_gemma":[0.9609779,0.0007418828,0.03192349,0.000115402,0.0000193889,0.0001578843,0.0005460668,0.00007613801,0.00544188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027687,"threshold_uncertainty_score":0.003437936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303877666976815,"score_gpt":0.2544786576266637,"score_spread":0.2414398809568956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}