{"id":"W3198441495","doi":"10.1186/s40035-021-00259-w","title":"Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment","year":2021,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Research Foundation; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Pfizer; BioClinica; Biogen; Ministry of Science and ICT, South Korea; Seoul National University; Genentech; Seoul National University Bundang Hospital; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Internal medicine; Hazard ratio; Dementia; Medicine; Alzheimer's Disease Neuroimaging Initiative; Proportional hazards model; Oncology; Neurology; Disease; Confidence interval; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000555,0.0000840096,0.0001056752,0.00003832006,0.00005741731,0.000006464197,0.00002398318,0.00006622767,0.000007384348],"category_scores_gemma":[0.00009838126,0.00007895256,0.00003342861,0.00008535152,0.0000152992,0.000007537586,0.00001222596,0.00004425928,3.109259e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000674805,"about_ca_system_score_gemma":0.00007939531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007956975,"about_ca_topic_score_gemma":0.0004693968,"domain_scores_codex":[0.999148,0.0001330202,0.0002411758,0.0002870937,0.00008567162,0.0001050743],"domain_scores_gemma":[0.9995525,0.00004535754,0.00009224956,0.0000676304,0.000205223,0.00003696734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000762413,0.0002024974,0.7543912,0.00004017703,0.00006833042,2.986204e-7,0.000178874,0.01098979,0.2302336,0.00007522125,0.00004756411,0.003009982],"study_design_scores_gemma":[0.001113825,0.000536354,0.8494191,0.00002490775,0.0000498146,0.00000331502,0.00003116293,0.00564289,0.1429714,0.00007030415,0.00005252745,0.00008442753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735358,0.0004807483,0.02482795,0.0004269831,0.00005006278,0.0005341511,0.0001270771,0.000003254487,0.00001398091],"genre_scores_gemma":[0.9943669,0.00008721617,0.004636822,0.00008551813,0.00005748024,0.0001122979,0.0006323783,0.000008484461,0.00001285098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09502784,"threshold_uncertainty_score":0.3219592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977713776574116,"score_gpt":0.2962843146225877,"score_spread":0.2765071768568466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}