{"id":"W3198441495","doi":"10.1186/s40035-021-00259-w","title":"Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment","year":2021,"lang":"en","type":"article","venue":"Translational Neurodegeneration","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; U.S. National Library of Medicine; IXICO; H. Lundbeck A/S; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Research Foundation; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Pfizer; BioClinica; Biogen; Ministry of Science and ICT, South Korea; Seoul National University; Genentech; Seoul National University Bundang Hospital; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Internal medicine; Hazard ratio; Dementia; Medicine; Alzheimer's Disease Neuroimaging Initiative; Proportional hazards model; Oncology; Neurology; Disease; Confidence interval; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002608855,0.0006293155,0.0005447262,0.001185828,0.0003595225,0.0007666058,0.0005606242,0.0005493253,0.002216385],"category_scores_gemma":[0.007820238,0.0002862293,0.001627287,0.001173954,0.000464319,0.0004246042,0.0006209633,0.0009993317,0.0002893012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800306,"about_ca_system_score_gemma":0.000427653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006037404,"about_ca_topic_score_gemma":0.003697653,"domain_scores_codex":[0.9985233,0.0007831121,0.00009935513,0.0002788956,0.0001874169,0.000127989],"domain_scores_gemma":[0.9907675,0.004776708,0.002270245,0.001002448,0.0004334631,0.0007495459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003098619,0.00002343398,0.9971203,0.00000877851,0.0004120724,0.0001011361,0.00001972409,0.0004044198,0.0001989688,0.00003975529,0.00005650209,0.001305153],"study_design_scores_gemma":[0.000004893885,0.00007977727,0.9967321,0.000003579353,0.0001266009,0.00015564,0.00002176833,0.002614174,0.00006004591,0.0001494484,0.00004544037,0.000006556528],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979674,0.0003880396,0.0007745997,0.00008694096,0.0000116098,0.000005916457,0.0003286482,0.00002539726,0.0004112764],"genre_scores_gemma":[0.9995333,0.00004082873,0.0001269525,0.000006571005,0.00001028822,0.000002539059,0.0001893877,0.000003462987,0.00008668438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006037404,"threshold_uncertainty_score":0.0137971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01977713776574116,"score_gpt":0.2962843146225877,"score_spread":0.2765071768568466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}