{"id":"W3198456384","doi":"10.1242/dev.198614","title":"Developmental single-cell transcriptomics in the <i>Lytechinus variegatus</i> sea urchin embryo","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Klarman Cell Observatory, Broad Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Biology; Endoderm; Gastrulation; Lytechinus variegatus; Ectoderm; Mesoderm; Developmental biology; Sea urchin; Germ layer; Embryo; Cell biology; Cleavage (geology); Embryogenesis; Embryonic stem cell; Genetics; Gene; Paleontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062439,0.0002348168,0.0001599353,0.00005489466,0.0001823709,0.00004216453,0.0002811845,0.0002062199,0.00003532069],"category_scores_gemma":[0.00002942218,0.0001979472,0.0000628667,0.0002503273,0.00006446355,0.000007112495,0.0001172583,0.0001652454,0.00004756478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000846002,"about_ca_system_score_gemma":0.0005874631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004858059,"about_ca_topic_score_gemma":0.0002745768,"domain_scores_codex":[0.9984432,0.000143974,0.000380932,0.0004657487,0.0002015127,0.0003645898],"domain_scores_gemma":[0.9996254,0.00001934744,0.00006111825,0.0001820339,0.00005113711,0.00006099857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008915739,0.0004511489,0.01274407,0.00002855566,0.00006379344,0.00006371169,0.001977923,0.00003418476,0.9614677,0.0001001327,0.003301414,0.01967814],"study_design_scores_gemma":[0.0007343194,0.00003931998,0.06862447,0.00001454946,0.00000658785,0.0001469844,0.0005192868,0.000006348325,0.724901,0.00007941602,0.2046094,0.0003182757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861014,0.0006334822,0.001454634,0.0003768831,0.0002308053,0.0002314302,0.000009658015,0.00001745497,0.01094421],"genre_scores_gemma":[0.9776497,0.00005999105,0.01726665,0.002032278,0.00005977075,0.00005347733,0.0009004521,0.00002124601,0.001956376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2365667,"threshold_uncertainty_score":0.8072052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058280709331709,"score_gpt":0.2048869538627366,"score_spread":0.1943041467694195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}