{"id":"W3198456384","doi":"10.1242/dev.198614","title":"Developmental single-cell transcriptomics in the <i>Lytechinus variegatus</i> sea urchin embryo","year":2021,"lang":"en","type":"article","venue":"Development","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Klarman Cell Observatory, Broad Institute; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Burroughs Wellcome Fund","keywords":"Biology; Endoderm; Gastrulation; Lytechinus variegatus; Ectoderm; Mesoderm; Developmental biology; Sea urchin; Germ layer; Embryo; Cell biology; Cleavage (geology); Embryogenesis; Embryonic stem cell; Genetics; Gene; Paleontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104812,0.0001283275,0.0003099857,0.0002357109,0.0002027738,0.0003271336,0.0001406462,0.0001642841,0.0006507594],"category_scores_gemma":[0.0001544271,0.0001249558,0.0002926075,0.0003233375,0.0001687002,0.0001225952,0.0001815134,0.0001658103,0.0002652247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257161,"about_ca_system_score_gemma":0.0002608402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0055929,"about_ca_topic_score_gemma":0.01540665,"domain_scores_codex":[0.9999338,0.000005471151,0.000002732054,0.00003649408,0.00001323266,0.000008212034],"domain_scores_gemma":[0.9999373,0.00002285745,0.00001141507,0.000008375086,0.00001217782,0.000007839824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813823,0.00001308952,0.01829105,0.0002735577,0.00006482773,0.0001431565,0.0001294622,0.005812442,0.9617602,0.0004144338,0.0007558839,0.01216059],"study_design_scores_gemma":[0.00002706692,0.0001710277,0.6371537,0.00003855829,0.0001514419,0.0004323021,0.0004085562,0.07660259,0.2697813,0.001155565,0.01400912,0.00006870547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727423,0.0006140103,0.01288855,0.0000594466,0.00001515516,0.00001557012,0.01211742,0.0004212094,0.001126393],"genre_scores_gemma":[0.9672469,0.0004910351,0.01393557,0.0001027639,0.000005993615,0.00007204252,0.01661855,0.0001393016,0.001387811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0055929,"threshold_uncertainty_score":0.01112074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058280709331709,"score_gpt":0.2048869538627366,"score_spread":0.1943041467694195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}