{"id":"W3198461294","doi":"10.1136/bmjopen-2021-051003","title":"Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial)","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Trauma, Hemostasis, Coagulopathy, Resuscitation","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; London Health Sciences Centre; McMaster University; St. Michael's Hospital; Kingston General Hospital; Health Sciences Centre; Defence Research and Development Canada; University Health Network; University of Toronto; Sinai Health System; Sunnybrook Health Science Centre","funders":"Octapharma; Canadian Institute for Military and Veteran Health Research; Canadian Blood Services","keywords":"Medicine; Interim analysis; Clotting factor; Coagulopathy; Prothrombin complex concentrate; Randomized controlled trial; Resuscitation; Informed consent; Clinical trial; Declaration of Helsinki; Emergency medicine; Data monitoring committee; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04989031,0.00631417,0.008525814,0.001910958,0.003350602,0.005276724,0.003780024,0.008218313,0.1364761],"category_scores_gemma":[0.06896582,0.002933663,0.004956539,0.0031988,0.004418924,0.003926001,0.002168247,0.01329305,0.02968459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004707841,"about_ca_system_score_gemma":0.01602162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00120926,"about_ca_topic_score_gemma":0.002770084,"domain_scores_codex":[0.9475257,0.03758257,0.004802288,0.003583836,0.003945947,0.002559716],"domain_scores_gemma":[0.969942,0.007612136,0.005616779,0.007403409,0.005495307,0.003930381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8435894,0.006982828,0.0006383923,0.02032465,0.001846214,0.0004529379,0.0006876037,0.001444786,0.002123293,0.01257028,0.0729884,0.03635127],"study_design_scores_gemma":[0.9040981,0.01304138,0.00144743,0.004796351,0.000553627,0.000157963,0.0001080971,0.002538455,0.00101853,0.004077842,0.06803145,0.0001308202],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001667756,0.000248436,0.002503885,0.000456813,0.0009942198,0.9895372,0.002170618,0.000197094,0.002223984],"genre_scores_gemma":[0.002897402,0.0001373727,0.003089383,0.0003406791,0.0001895531,0.9915383,0.0005571482,0.00002694777,0.001223164],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1364761,"threshold_uncertainty_score":0.4565581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1050341235814809,"score_gpt":0.4156621406037239,"score_spread":0.310628017022243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}