{"id":"W3198512485","doi":"10.1016/j.celrep.2021.109625","title":"Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity","year":2021,"lang":"en","type":"article","venue":"Cell Reports","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"Weill Cornell Medical College; National Cancer Institute; Prostate Cancer Foundation; National Institutes of Health; MetLife Foundation; Damon Runyon Cancer Research Foundation","keywords":"Prostate cancer; Androgen receptor; Chromatin; Biology; Chromoplexy; Carcinogenesis; Prostate; Epigenomics; Phenotype; Cancer research; Mutant; Epigenetics; Genetics; Cancer; Gene; DNA methylation; PCA3; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001223173,0.0002556445,0.0002746465,0.0002705496,0.000155722,0.0003304758,0.0002101502,0.0002563934,0.002199026],"category_scores_gemma":[0.0001385537,0.0001722091,0.0002365008,0.0001688355,0.0002765697,0.0001976004,0.000237781,0.0006452273,0.0002949838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002279179,"about_ca_system_score_gemma":0.0002014631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008541205,"about_ca_topic_score_gemma":0.00156017,"domain_scores_codex":[0.9998469,0.00001923427,0.00001052367,0.0000360065,0.00005128509,0.00003601635],"domain_scores_gemma":[0.9998808,0.00002400487,0.00002471821,0.0000250584,0.000008211325,0.00003721334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008353682,0.0000262081,0.0002438829,0.00001830984,0.00000558671,0.00002871707,0.00001477419,0.0001633824,0.9977772,0.0001261674,0.00005023908,0.001462108],"study_design_scores_gemma":[0.000007482243,0.0004882836,0.004131092,0.000002994903,0.00001044392,0.0002697014,0.00003247592,0.0006496806,0.9915659,0.00005899902,0.00277616,0.000006792621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919423,0.001729898,0.00378958,0.00009735961,0.00003308343,0.00003753977,0.0006676553,0.0002459228,0.001456632],"genre_scores_gemma":[0.9961647,0.0006126294,0.001197942,0.00003890834,0.000004501751,0.00002114921,0.0004225605,0.00004528618,0.001492306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199026,"threshold_uncertainty_score":0.007356465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009636414892716128,"score_gpt":0.2617658211857947,"score_spread":0.2521294062930786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}