{"id":"W3198540846","doi":"10.1016/j.jbc.2021.101177","title":"Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada; Fondation Leducq; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"LDL receptor; Asialoglycoprotein receptor; PCSK9; Biology; Furin; Kexin; Molecular biology; Receptor; Proprotein convertase; Chemistry; Biochemistry; Cholesterol; Lipoprotein; Hepatocyte","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008014416,0.0002321928,0.0002159157,0.0001836938,0.0001645866,0.0002959726,0.0001879117,0.0002356549,0.002098932],"category_scores_gemma":[0.00008431271,0.0000889911,0.0002566917,0.0001269336,0.0002158889,0.0001634684,0.0001672895,0.0004703243,0.0007938971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398349,"about_ca_system_score_gemma":0.0002042723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009134097,"about_ca_topic_score_gemma":0.001031925,"domain_scores_codex":[0.9999108,0.00001095231,0.000007508418,0.00002106206,0.00002725279,0.00002233357],"domain_scores_gemma":[0.9999554,0.000004540074,0.00001681548,0.000004704897,0.000005956988,0.0000125767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001291951,0.00001046094,0.0007185761,0.00005276439,0.00001087182,0.0002462215,0.00001143244,0.00009661344,0.9951845,0.000291442,0.000151021,0.003096942],"study_design_scores_gemma":[0.00002397997,0.0001782792,0.01504373,0.000006997676,0.00003083668,0.003049744,0.00005026463,0.001898269,0.9649619,0.0001833306,0.0145579,0.0000148202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838448,0.002415866,0.008807176,0.0004668903,0.00008392715,0.00003250582,0.0009077793,0.0001531109,0.003287894],"genre_scores_gemma":[0.9835188,0.001291753,0.005164553,0.0001234952,0.00001767669,0.00002129115,0.001471773,0.00002499125,0.008365646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098932,"threshold_uncertainty_score":0.007021606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549628315776507,"score_gpt":0.2543332051582681,"score_spread":0.228836922000503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}