{"id":"W3198546278","doi":"10.1093/ntr/ntab183","title":"Human Abuse Liability Assessment of Tobacco and Nicotine Products: Approaches for Meeting Current Regulatory Recommendations","year":2021,"lang":"en","type":"review","venue":"Nicotine & Tobacco Research","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Abuse liability; Product liability; Liability; Product (mathematics); Medicine; Business; Risk analysis (engineering); Environmental health; Pharmacology; Drug; Accounting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007668169,0.0005382164,0.002280261,0.00066911,0.0004309668,0.0001269012,0.00039808,0.0004414686,0.0001458185],"category_scores_gemma":[0.001490472,0.0004661277,0.0005031655,0.00134327,0.0003397349,0.0001593784,0.000387238,0.001807607,0.000001626736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007619915,"about_ca_system_score_gemma":0.001676771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005076283,"about_ca_topic_score_gemma":0.0000263445,"domain_scores_codex":[0.9937372,0.001082589,0.001676971,0.001411563,0.001334482,0.0007572087],"domain_scores_gemma":[0.994821,0.0008246307,0.0006666945,0.001661677,0.001771807,0.0002541643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001014711,0.001393361,0.02208509,0.0264561,0.0002105147,0.000001060244,0.0001462162,7.719041e-7,0.00003121201,0.001054419,0.004279348,0.9443318],"study_design_scores_gemma":[0.001320158,0.0005074582,0.009079395,0.02776715,0.001724914,0.0000285669,0.0004481162,0.00001401717,0.0002230459,0.00003859042,0.958307,0.0005415321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03302655,0.9593647,0.00002369539,0.0006191241,0.0004402142,0.00559125,0.000162881,0.00008473931,0.0006869082],"genre_scores_gemma":[0.005874054,0.9851049,0.002341924,0.00001010939,0.0009758074,0.001565781,0.003124028,0.0001608089,0.0008425767],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9540277,"threshold_uncertainty_score":0.999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3950939603486891,"score_gpt":0.5199911991061632,"score_spread":0.1248972387574741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}