{"id":"W3198549098","doi":"10.33380/2305-2066-2021-10-3-105-113","title":"Determination of Lappaconitin, Diterpene Alkaloide Obtained from Plants <i>Aconitum leucostomum</i>, and its Active Metabolite N-desacetyllappaconitin in Human Plasma and Blood","year":2021,"lang":"en","type":"article","venue":"Drug development & registration","topic":"Plant-based Medicinal Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Public Health Association","funders":"","keywords":"Alkaloid; Chemistry; Chromatography; Diterpene; High-performance liquid chromatography; Protein precipitation; Pharmacokinetics; Metabolite; Aconitum; Quantitative analysis (chemistry); Active metabolite; Pharmacology; Stereochemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000230991,0.0003528929,0.0001455146,0.000407693,0.0001866791,0.0001607972,0.0001770341,0.0004282411,0.0008155746],"category_scores_gemma":[0.0004017983,0.0001201332,0.0001438489,0.0002321826,0.0001924964,0.0001860125,0.0001276379,0.0002554895,0.0002624334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919343,"about_ca_system_score_gemma":0.00031905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009323615,"about_ca_topic_score_gemma":0.001603444,"domain_scores_codex":[0.9997105,0.00004255618,0.00002000508,0.0000882142,0.0001239366,0.00001471928],"domain_scores_gemma":[0.999863,0.00002998813,0.00003601044,0.00001103922,0.00004276925,0.00001716967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003542811,0.00004747128,0.004086015,0.0002067359,0.00003122469,0.0001604686,0.00005238111,0.0001280688,0.9739213,0.00009657303,0.0001567139,0.02075875],"study_design_scores_gemma":[0.00004069984,0.0009021728,0.02376184,0.00003765714,0.00006874,0.00228936,0.00005955275,0.002415414,0.9647653,0.0001207401,0.005517252,0.00002122523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9143855,0.02126124,0.05632461,0.0003463926,0.0001296625,0.0002993371,0.00165366,0.0006047102,0.004994846],"genre_scores_gemma":[0.9510792,0.005332041,0.03685499,0.0003121914,0.00004422983,0.0002536041,0.001228243,0.00002527013,0.004870226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009323615,"threshold_uncertainty_score":0.002728343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05625091011436616,"score_gpt":0.3656614644053199,"score_spread":0.3094105542909537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}