{"id":"W3198688798","doi":"10.1101/2021.08.29.458125","title":"NBI-921352, a First-in-Class, Na <sub>V</sub> 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in <i>Scn8a</i> Gain-of-Function Mice, and Wild-Type Mice and Rats","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"Neurocrine Biosciences","keywords":"Sodium channel; Excitatory postsynaptic potential; Chemistry; Gene isoform; Sodium; Inhibitory postsynaptic potential; Glutamatergic; Gain of function; Epilepsy; Wild type; Selectivity; Biophysics; Receptor; Neuroscience; Mutation; Biology; Biochemistry; Mutant; Glutamate receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009275168,0.0005456947,0.0004045692,0.0002985354,0.0001395239,0.0002429214,0.0003579669,0.0002525573,0.002515344],"category_scores_gemma":[0.00007981468,0.0001791644,0.0003151258,0.0001742814,0.0001917962,0.0002625117,0.0001432887,0.0008923486,0.0009041452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003291643,"about_ca_system_score_gemma":0.0003652042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001550662,"about_ca_topic_score_gemma":0.003165926,"domain_scores_codex":[0.9999201,0.000006387424,0.000008262031,0.0000176997,0.00002811399,0.00001936515],"domain_scores_gemma":[0.9999589,0.000002719904,0.00001419734,0.000003270465,0.000005322501,0.00001560014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000489171,0.0001086996,0.0002779627,0.0001024375,0.00002785158,0.00006403839,0.00001211902,0.0001106605,0.9856313,0.0002267162,0.0008863898,0.0120626],"study_design_scores_gemma":[0.0004668908,0.00263255,0.007334305,0.00002670295,0.0001286584,0.00119505,0.00002638576,0.001232795,0.9653335,0.0001153674,0.02148602,0.00002180562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9498093,0.01882549,0.009239861,0.0006351399,0.0002874714,0.0002034465,0.003516239,0.001285606,0.01619751],"genre_scores_gemma":[0.9663106,0.009416737,0.005787173,0.0003192983,0.0000313405,0.0001477131,0.005977926,0.0001068694,0.01190233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002515344,"threshold_uncertainty_score":0.008414686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009591081506268176,"score_gpt":0.2009055554149675,"score_spread":0.1913144739086993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}