{"id":"W3198692410","doi":"10.1136/gutjnl-2021-iddf.81","title":"IDDF2021-ABS-0079 Switching from tenofovir disoproxil fumarate (TDF) and/or other oral antivirals (OAVS) to tenofovir alafenamide (TAF) in virally suppressed chronic hepatitis B (CHB) patients with hepatic impairment: final 2-year efficacy and safety results from a phase 2","year":2021,"lang":"en","type":"article","venue":"","topic":"Hepatitis C virus research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; Université de Montréal","funders":"","keywords":"Tenofovir alafenamide; Medicine; Internal medicine; Creatinine; Gastroenterology; Adverse effect; HBeAg; Renal function; Viral load; Hepatitis B virus; HBsAg; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009182841,0.0005017598,0.0008182349,0.0001305809,0.0003468866,0.0005587595,0.0003538909,0.0008269661,0.004978267],"category_scores_gemma":[0.0003867849,0.0002127999,0.0005523175,0.0001664795,0.0004473227,0.0003317543,0.0002249144,0.001587849,0.001110426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004348073,"about_ca_system_score_gemma":0.001186935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346986,"about_ca_topic_score_gemma":0.002875734,"domain_scores_codex":[0.9997143,0.0001175624,0.00002655056,0.00002943482,0.00003640134,0.00007573555],"domain_scores_gemma":[0.9997075,0.00004059089,0.00005473443,0.00002887858,0.00002909317,0.0001391618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5096829,0.05492556,0.02924428,0.0007005409,0.0007840809,0.0008152802,0.0002665456,0.002167935,0.1145877,0.0005906743,0.02311813,0.2631164],"study_design_scores_gemma":[0.4560914,0.4439686,0.0594155,0.0001032949,0.0003940806,0.001095517,0.0001426612,0.002247312,0.01508569,0.0004175176,0.02098184,0.0000566052],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984014,0.001174494,0.0006749764,0.0008265099,0.00019914,0.00313196,0.003190805,0.0001590701,0.006629115],"genre_scores_gemma":[0.9770685,0.0008708564,0.002870414,0.002865078,0.0002099525,0.002985021,0.006886657,0.00004476942,0.006198695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004978267,"threshold_uncertainty_score":0.01665395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.022599151893373,"score_gpt":0.3059418052614536,"score_spread":0.2833426533680806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}