{"id":"W3198745106","doi":"10.1084/jem.20210777","title":"Arkadia-SKI/SnoN signaling differentially regulates TGF-β–induced iTreg and Th17 cell differentiation","year":2021,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Cancer Research Institute; Medical Research Council; National Cancer Institute; National Institutes of Health; York University; Howard Hughes Medical Institute","keywords":"Cell biology; Cellular differentiation; Signal transduction; Cell; SMAD; Biology; Transforming growth factor; Ubiquitin ligase; Cell signaling; Chemistry; Ubiquitin; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778438,0.0003227705,0.0003353631,0.0003934146,0.0002069159,0.0005347691,0.0001719667,0.0002856497,0.002265141],"category_scores_gemma":[0.00008220645,0.0002481527,0.0003235293,0.0001869935,0.0004791059,0.0002975154,0.0002640867,0.0008927972,0.0007071128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992236,"about_ca_system_score_gemma":0.0003822191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481963,"about_ca_topic_score_gemma":0.001259124,"domain_scores_codex":[0.9997258,0.00003633162,0.00002956435,0.00006188345,0.00005615798,0.00009027014],"domain_scores_gemma":[0.9998456,0.00001622198,0.00005014217,0.00001475629,0.000009623946,0.00006351077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002180933,0.00002013926,0.0002559729,0.000026636,0.000003388574,0.00003175595,0.00001548425,0.00006231868,0.9986535,0.0001058101,0.00002086391,0.0005861247],"study_design_scores_gemma":[0.00002580768,0.0002104148,0.005387382,0.00000633959,0.00001625654,0.0001684041,0.00007784576,0.0007968902,0.9914103,0.00005594815,0.001838087,0.000006407862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947559,0.001296406,0.00133501,0.00008034019,0.000033763,0.00001625146,0.0005376614,0.0001103649,0.001834274],"genre_scores_gemma":[0.9953259,0.000636825,0.0009266196,0.00004267782,0.000004440507,0.00002152859,0.0004109266,0.00002391191,0.002607131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002265141,"threshold_uncertainty_score":0.007577717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562065579279608,"score_gpt":0.2427843880938786,"score_spread":0.2271637323010825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}