{"id":"W3198757636","doi":"10.1186/s13041-021-00841-3","title":"Modeling PTEN overexpression-induced microcephaly in human brain organoids","year":2021,"lang":"en","type":"article","venue":"Molecular Brain","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Canada Research Chairs; University of Toronto; University of New Brunswick; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund; Ontario Institute for Regenerative Medicine; Canada Excellence Research Chairs, Government of Canada; Simons Foundation","keywords":"PTEN; Tensin; Microcephaly; Organoid; Biology; PI3K/AKT/mTOR pathway; Cancer research; Human brain; Protein kinase B; Macrocephaly; Phenotype; Cell biology; Neuroscience; Signal transduction; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000256532,0.0005487823,0.0003369597,0.0004373734,0.000239937,0.0003438937,0.0004881963,0.0004930992,0.0007071226],"category_scores_gemma":[0.0001272209,0.000260653,0.0004483919,0.0002868724,0.0003753593,0.0002152415,0.0005461981,0.0006615959,0.0002557727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006239479,"about_ca_system_score_gemma":0.0004244205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002626945,"about_ca_topic_score_gemma":0.002814573,"domain_scores_codex":[0.999848,0.00001779299,0.00001079337,0.00004398133,0.00005424167,0.00002510741],"domain_scores_gemma":[0.9998839,0.00003004739,0.00003013126,0.00001846328,0.000009927154,0.00002755815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008680415,0.00004765501,0.0002187275,0.00005448636,0.00001620134,0.0002926554,0.0000538543,0.005818248,0.9915966,0.0005647495,0.00009774826,0.001152289],"study_design_scores_gemma":[0.00002843767,0.0002946318,0.0009944297,0.000008736481,0.00003656759,0.0003915196,0.00004796018,0.01238081,0.9819848,0.000204524,0.003613845,0.00001382915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9524083,0.001858107,0.03895208,0.0001917788,0.0001176565,0.0002651574,0.001822933,0.0004202334,0.003963764],"genre_scores_gemma":[0.9790461,0.001329961,0.01599232,0.00003742906,0.000005673877,0.0002459524,0.0007682894,0.00004985687,0.00252438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002626945,"threshold_uncertainty_score":0.005223334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212834098259194,"score_gpt":0.2795910565218298,"score_spread":0.2674627155392378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}