{"id":"W3198818236","doi":"10.3390/ijms22179550","title":"The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer","year":2021,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Prostate cancer; Immunotherapy; Immune system; Tumor microenvironment; Somatic cell; Cancer; PTEN; Cancer research; Biology; Cancer immunotherapy; Immunology; Medicine; Gene; Genetics; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003865114,0.0005586471,0.00094489,0.001438329,0.0001685092,0.0006300255,0.00054522,0.0007535603,0.001735192],"category_scores_gemma":[0.000465756,0.0001599501,0.0003938218,0.001247342,0.0003443102,0.0008139791,0.0004535665,0.001120975,0.0008269275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003952265,"about_ca_system_score_gemma":0.0005903021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005648564,"about_ca_topic_score_gemma":0.00101516,"domain_scores_codex":[0.9998643,0.00002611936,0.0000169528,0.00002120692,0.00005501884,0.00001628491],"domain_scores_gemma":[0.9998215,0.00009567339,0.0000246624,0.000004771513,0.00003879359,0.00001469494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008055707,0.00005095412,0.0003107092,0.01321874,0.00009107374,0.0002514545,0.00004419134,0.0003958669,0.002429693,0.002530219,0.01626681,0.9643297],"study_design_scores_gemma":[0.00002298367,0.0001861211,0.002437899,0.004393977,0.0001955979,0.003210358,0.00006328165,0.000136225,0.0009345899,0.00261463,0.9857801,0.00002417698],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001342904,0.999036,0.00006986483,0.0001649367,0.0001175867,0.000001965642,0.000007521491,0.000004577516,0.0004633507],"genre_scores_gemma":[0.0006792895,0.9987634,0.00008000262,0.0001243835,0.000108319,0.000002824944,0.00001242183,7.088285e-7,0.0002285645],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001735192,"threshold_uncertainty_score":0.005804777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772058643760874,"score_gpt":0.3308877309457287,"score_spread":0.3131671445081199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}