{"id":"W3198832081","doi":"10.1111/jnc.15504","title":"Palmitate‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines","year":2021,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Endocrinology; Neuropeptide Y receptor; Proinflammatory cytokine; Internal medicine; Orexigenic; Chemistry; Ceramide; Intracellular; Biology; Neuropeptide; Biochemistry; Inflammation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299433,0.0004880009,0.0003302532,0.0002149359,0.0001855699,0.0002078234,0.0001029125,0.0002329719,0.001167929],"category_scores_gemma":[0.00009545678,0.0001501503,0.0003999282,0.0001594827,0.0002611649,0.0002199022,0.0003175276,0.0004726863,0.0003861869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002265592,"about_ca_system_score_gemma":0.0002645567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000366707,"about_ca_topic_score_gemma":0.0007291847,"domain_scores_codex":[0.9998519,0.00002473509,0.0000162196,0.00003318258,0.00003085406,0.0000430236],"domain_scores_gemma":[0.9999212,0.00001235853,0.00001842724,0.00001009408,0.00001512875,0.00002273452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002325933,0.00001270345,0.0001499616,0.0000315028,0.000003437814,0.00004780734,0.000006119929,0.000008923477,0.9990245,0.0000177578,0.000006261421,0.0004584575],"study_design_scores_gemma":[0.00002159105,0.0003359838,0.006176256,0.000007321702,0.00001164996,0.000185888,0.00002205519,0.0001366598,0.9923242,0.00003580323,0.0007401297,0.000002480068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911022,0.002896539,0.003455382,0.0001129143,0.0000516408,0.00006033346,0.0004187162,0.00004575575,0.00185649],"genre_scores_gemma":[0.9916788,0.00227342,0.002812548,0.00008520706,0.00002682694,0.0001301664,0.0006586332,0.00001356456,0.002320889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167929,"threshold_uncertainty_score":0.003907084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669838135269551,"score_gpt":0.2513145991025609,"score_spread":0.2246162177498654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}