{"id":"W3198853168","doi":"10.15252/embj.2021108863","title":"Autophagy in major human diseases","year":2021,"lang":"en","type":"review","venue":"The EMBO Journal","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1549,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; Kenneth Rainin Foundation; National Cancer Institute; Cancer Research UK; Biotechnology and Biological Sciences Research Council; National Institute of Allergy and Infectious Diseases; Kennedy Trust for Rheumatology Research; Wellcome Trust; Bristol-Myers Squibb; AstraZeneca; Pfizer; National Institute on Aging","keywords":"Biology; Autophagy; Virology; Computational biology; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00058658,0.0009720363,0.00133493,0.002157155,0.0003893244,0.0009225171,0.0007539159,0.001138009,0.008662676],"category_scores_gemma":[0.0005615537,0.0001965401,0.0004260746,0.001825306,0.0005697132,0.001001748,0.001071058,0.001986934,0.007881161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006736304,"about_ca_system_score_gemma":0.00121011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008300131,"about_ca_topic_score_gemma":0.001427305,"domain_scores_codex":[0.9997478,0.00004815358,0.00003695114,0.00003834447,0.0001028251,0.0000258285],"domain_scores_gemma":[0.9997664,0.00008242901,0.00003429905,0.00001113662,0.0000667689,0.00003895037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005818583,0.00003762855,0.0001059485,0.01017569,0.00005263966,0.0002114531,0.00007346441,0.0001670212,0.0008586738,0.00489078,0.1028534,0.8805152],"study_design_scores_gemma":[0.000008451823,0.00003283948,0.000378455,0.00314354,0.00003214113,0.0008107095,0.00003101382,0.00002056389,0.0001087717,0.002140734,0.9932852,0.000007691107],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005236617,0.9969333,0.00009333133,0.0004086726,0.0003929182,0.000005065099,0.00002910908,0.00001600751,0.002069199],"genre_scores_gemma":[0.0005068664,0.9967695,0.0001706368,0.0004673399,0.0004584199,0.000008937134,0.00005952657,0.000002880572,0.001555887],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008662676,"threshold_uncertainty_score":0.02897954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05485157723561999,"score_gpt":0.402436607474861,"score_spread":0.347585030239241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}