{"id":"W3198872327","doi":"10.1126/scitranslmed.aaz6804","title":"A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma","year":2021,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Terry Fox Foundation; Li Ka Shing Foundation","keywords":"Blockade; Immune checkpoint; Immune system; Reprogramming; Immunity; Medicine; Hepatocellular carcinoma; Cancer research; Immunology; Immunotherapy; Biology; Receptor; Internal medicine; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008678567,0.000115431,0.0002045991,0.0001922227,0.0001193718,0.000007998086,0.0001660204,0.00005327561,0.00002907697],"category_scores_gemma":[0.0005396231,0.0001056737,0.00004731684,0.0008048536,0.001216635,0.00001283004,0.00006467896,0.0001711708,0.000001279235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000249421,"about_ca_system_score_gemma":0.0006016949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002310696,"about_ca_topic_score_gemma":0.00005083078,"domain_scores_codex":[0.9984203,0.00008487606,0.0003727966,0.0003750513,0.0004950291,0.0002519398],"domain_scores_gemma":[0.9992151,0.00004566107,0.00006795352,0.0002267612,0.0003441934,0.0001002913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007603122,0.0001009801,0.02348459,0.00003265084,0.000007978187,0.00001244161,0.0005397354,0.00003335996,0.9754221,0.00004085469,0.000007238866,0.0002420396],"study_design_scores_gemma":[0.001314809,0.0001579528,0.1890648,0.00007301219,0.000006782218,0.00003530861,0.0001706484,0.0004526662,0.8084928,0.00008960943,0.00005651928,0.0000850588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949572,0.003293016,0.0001442453,0.0008943251,0.00007646808,0.0001847253,0.000009536417,0.00000401912,0.0004364578],"genre_scores_gemma":[0.9991592,0.00005999302,0.0005255571,0.00001623876,0.00009506972,0.000007528186,0.000059006,0.000008580427,0.00006888425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1669293,"threshold_uncertainty_score":0.4482742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391930328768287,"score_gpt":0.2819006950106099,"score_spread":0.2679813917229271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}