{"id":"W3198883649","doi":"10.1016/j.plasmid.2021.102598","title":"Sequence polarity between the promoter and the adjacent gene modulates promoter activity","year":2021,"lang":"en","type":"article","venue":"Plasmid","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs; Genome Canada","keywords":"Promoter; Promoter activity; Gene; Biology; Plasmid; Context (archaeology); Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002112002,0.0003555604,0.0002655696,0.0002989336,0.0002351311,0.0006402078,0.0002432361,0.0003549902,0.002414015],"category_scores_gemma":[0.0005642782,0.0002657079,0.0001904082,0.0001947468,0.0004826854,0.0004201911,0.0003360938,0.001102819,0.0006765105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003233619,"about_ca_system_score_gemma":0.0004225701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003025658,"about_ca_topic_score_gemma":0.0007835549,"domain_scores_codex":[0.9997765,0.00005572224,0.00001443695,0.00003983615,0.00005342875,0.00006010509],"domain_scores_gemma":[0.9994529,0.0002901062,0.00008349482,0.00003574216,0.0000363539,0.0001013881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005796134,0.00001496474,0.0001031173,0.00001956468,0.000001021373,0.0000211622,0.000008580901,0.00002650835,0.9990451,0.0002290617,0.00001153504,0.0004613432],"study_design_scores_gemma":[0.00001699544,0.0000971031,0.001213799,0.0000072632,0.000007846781,0.00008210925,0.00002978182,0.0008920302,0.996861,0.00009267878,0.000695129,0.000004360171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889829,0.000523446,0.007904162,0.0001763452,0.00006023264,0.00003618802,0.0001095468,0.00006727266,0.002139964],"genre_scores_gemma":[0.9947851,0.0002812509,0.003254044,0.00005617036,0.00002200557,0.0000234442,0.0002445982,0.00004474317,0.001288632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002414015,"threshold_uncertainty_score":0.008075714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01763898176613584,"score_gpt":0.2621408197646757,"score_spread":0.2445018379985399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}