{"id":"W3198949575","doi":"10.1021/acsomega.1c03781","title":"Weak Binding of Levamisole by the Cocaine-Binding Aptamer Does Not Interfere with an Aptamer-Based Detection Assay","year":2021,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Levamisole; Aptamer; Adulterant; Isothermal titration calorimetry; Chemistry; Binding site; Titration; Plasma protein binding; Biophysics; Biochemistry; Molecular biology; Biology; Inorganic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005164869,0.0007194888,0.0004610904,0.0002812497,0.0002315647,0.000442256,0.0005594861,0.0008581934,0.001290475],"category_scores_gemma":[0.001672489,0.0003524763,0.0002798249,0.0002893917,0.0004156653,0.0002638565,0.0002661092,0.0007068201,0.001037982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985048,"about_ca_system_score_gemma":0.0001978972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005677363,"about_ca_topic_score_gemma":0.00153036,"domain_scores_codex":[0.9985838,0.00028929,0.00009079383,0.0003025529,0.0006116086,0.0001219611],"domain_scores_gemma":[0.9986989,0.0005510205,0.0002159528,0.0001559842,0.0002985835,0.00007948027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001327546,0.000009015932,0.0001010307,0.00001231238,0.000003595906,0.00001115522,0.00001263427,0.00001691442,0.9992381,0.00001700769,0.00001595961,0.0005490313],"study_design_scores_gemma":[0.000001649645,0.00005660907,0.0005926373,0.000001798526,0.000005088794,0.00005384897,0.000007145919,0.0004928632,0.9983585,0.00001365143,0.0004133966,0.000002668359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8947676,0.001151308,0.09806259,0.0003208447,0.0001451966,0.0002232216,0.0004093252,0.0007198224,0.004200183],"genre_scores_gemma":[0.9281086,0.0008821231,0.06151189,0.0003466932,0.0000327113,0.0002794214,0.0007734388,0.0001403147,0.007924753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290475,"threshold_uncertainty_score":0.004317045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022759289907352,"score_gpt":0.2585749485530835,"score_spread":0.24834735565401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}