{"id":"W3198968419","doi":"10.1007/s00726-021-03078-5","title":"Oncogenic Ras expression increases cellular formate production","year":2021,"lang":"en","type":"article","venue":"Amino Acids","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Formate; Serine; Glycine; Formate dehydrogenase; Cytosol; Biochemistry; Chemistry; Cancer cell; Biology; Cell biology; Amino acid; Enzyme; Cancer; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205739,0.0001496128,0.0002211472,0.00007721539,0.00008553928,0.00001674893,0.00005761522,0.0001267113,0.0004037856],"category_scores_gemma":[0.0002275081,0.0001404888,0.0001255744,0.0002660351,0.00004579233,0.0001235748,0.00008146059,0.0002111063,0.00028615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001341949,"about_ca_system_score_gemma":0.0002135816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003497744,"about_ca_topic_score_gemma":0.000005357257,"domain_scores_codex":[0.998813,0.00005810788,0.0002331317,0.0003386902,0.0003041154,0.0002529086],"domain_scores_gemma":[0.9990718,0.00001448905,0.00007077817,0.0005470621,0.0001563557,0.0001394899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000954369,0.0001540351,0.001081983,0.00007959941,0.00004135484,0.0002986451,0.0001258223,0.00001175171,0.9886106,0.00002811978,0.005014182,0.004458518],"study_design_scores_gemma":[0.0009639583,0.0001212368,0.002076593,0.0002131329,0.0001342987,0.0004907002,0.0001326746,0.00004789429,0.9617711,0.00004843678,0.03385794,0.0001420846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909215,0.002954622,0.0008658709,0.0003702788,0.0005500785,0.0002655665,0.000006682162,0.0001510092,0.003914408],"genre_scores_gemma":[0.994291,0.0002542359,0.00109726,0.0002760097,0.0003837008,0.00003280432,0.0001929839,0.00003527962,0.003436714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02884376,"threshold_uncertainty_score":0.5728968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272426520763336,"score_gpt":0.2429300000855268,"score_spread":0.2302057348778934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}