{"id":"W3199062690","doi":"10.1021/acsptsci.1c00019","title":"Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation","year":2021,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Adenylyl cyclase; Chemistry; G protein-coupled receptor; Opioid; Agonist; Signal transduction; Functional selectivity; Receptor; μ-opioid receptor; G protein; Enkephalin; Pharmacology; Cell biology; Internal medicine; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002755904,0.00009977099,0.0001305715,0.00005213836,0.0006347091,0.00003095472,0.000176825,0.00003082539,0.00001984906],"category_scores_gemma":[0.00009868337,0.00006433336,0.00003490478,0.0006220918,0.001070978,0.000313836,0.00003075705,0.0001543023,5.703236e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001528594,"about_ca_system_score_gemma":0.0003147775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009358439,"about_ca_topic_score_gemma":0.000003127967,"domain_scores_codex":[0.9987618,0.0001277746,0.0002504057,0.0003924028,0.0002948106,0.0001727554],"domain_scores_gemma":[0.9982475,0.0009130439,0.0002158023,0.00008321297,0.000508767,0.00003165579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002828512,0.00007652085,0.0005014208,0.00002119793,0.00001250165,0.000001054832,0.0002636905,0.002978208,0.9945704,0.0008736345,0.0000275971,0.0003909674],"study_design_scores_gemma":[0.0004358145,0.0001242978,0.07073882,0.000007992386,0.00003571473,0.00002528808,0.0000615236,0.001469881,0.9265411,0.0004218675,0.00007383324,0.00006382215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970177,0.00002687875,0.0005812679,0.001784728,0.0001453323,0.0003685704,0.00005242337,0.00001113498,0.0000119123],"genre_scores_gemma":[0.9993154,0.00001732302,0.0001851286,0.0003072983,0.0000916833,0.00003584103,0.00001588103,0.000006839545,0.00002461189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0702374,"threshold_uncertainty_score":0.4881734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933514938580879,"score_gpt":0.2840455182906172,"score_spread":0.2547103689048084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}