{"id":"W3199077302","doi":"10.26434/chemrxiv.9275318.v1","title":"Total Synthesis of (–)-Picrotoxinin","year":2019,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Arnold and Mabel Beckman Foundation","keywords":"Stereochemistry; Chemistry; Demethylation; Stereoselectivity; Counterintuitive; Bond cleavage; Total synthesis; Cleavage (geology); Bicyclic molecule; Geminal; Biology; Philosophy; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.001354772,0.0007006298,0.001404647,0.0002626342,0.0001229363,0.00002409506,0.001034533,0.002168941,0.01234384],"category_scores_gemma":[0.0003341532,0.0007001031,0.0006748313,0.0001897481,0.000488278,0.00006670934,0.001063645,0.002635585,0.001036339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344404,"about_ca_system_score_gemma":0.0004257968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004699194,"about_ca_topic_score_gemma":0.000003453263,"domain_scores_codex":[0.9962568,0.0007862078,0.001017314,0.0009330524,0.0002396823,0.0007669728],"domain_scores_gemma":[0.9960154,0.001773672,0.0008335917,0.0008520463,0.0002155155,0.000309783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001695366,0.002460246,0.02919728,0.004323493,0.004457715,0.0001368052,0.001484667,0.005957063,0.7988587,0.002181882,0.1048481,0.04439867],"study_design_scores_gemma":[0.0009264982,0.00008729161,0.003699479,0.0001661688,0.0009623038,0.00002994674,0.00008063985,0.00168201,0.9410307,0.0009166969,0.04954438,0.0008739322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9521766,0.002201128,0.0000819277,0.0006763999,0.005621093,0.001268074,0.0001593393,0.0001646619,0.0376508],"genre_scores_gemma":[0.9935039,0.0007434348,0.0003126368,0.0007317765,0.0008078402,0.0004462434,0.00005842874,0.000107178,0.003288581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.142172,"threshold_uncertainty_score":0.9997415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.108341930582625,"score_gpt":0.4154856451571826,"score_spread":0.3071437145745576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}