{"id":"W3199082155","doi":"10.1093/eurheartj/ehab687","title":"Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death","year":2021,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University Health Network; Toronto General Hospital; University of New Brunswick; University of Toronto; Canada Research Chairs","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; British Heart Foundation; Wellcome Trust","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Short QT syndrome; Medicine; Genetic testing; Sudden cardiac death; Genetics; Phenocopy; Sudden death; Gene; Cardiology; Ryanodine receptor 2; Long QT syndrome; Internal medicine; Phenotype; Biology; QT interval","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06622902,0.0008387543,0.001227603,0.01436686,0.001363901,0.002587592,0.003010728,0.00149185,0.002138254],"category_scores_gemma":[0.1259217,0.0003021219,0.0023537,0.00544206,0.00318918,0.001433806,0.003437905,0.0009949759,0.0004297444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001539685,"about_ca_system_score_gemma":0.002775772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002321127,"about_ca_topic_score_gemma":0.004034664,"domain_scores_codex":[0.9649364,0.01065893,0.01010183,0.005261933,0.007942051,0.001098751],"domain_scores_gemma":[0.8083092,0.1125781,0.031256,0.007941005,0.03696143,0.002954215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009538704,0.00003827571,0.9627167,0.002305761,0.00102551,0.003484601,0.001694149,0.0006137367,0.00324478,0.001203738,0.001209479,0.02150932],"study_design_scores_gemma":[0.0002385892,0.000761893,0.9391738,0.00342238,0.003571599,0.01482171,0.002653888,0.006316616,0.006255726,0.004444685,0.01821403,0.000125164],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9400501,0.02531647,0.01406116,0.003324352,0.0005603437,0.001245812,0.005289248,0.0001674644,0.009985168],"genre_scores_gemma":[0.9856237,0.0013225,0.00926098,0.0004400989,0.0002130744,0.0002204636,0.002615488,0.00005364663,0.0002501458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06622902,"threshold_uncertainty_score":0.3502567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1066795574275833,"score_gpt":0.3500130328239232,"score_spread":0.2433334753963399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}