{"id":"W3199127221","doi":"10.1042/bcj20210629","title":"Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy","year":2021,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; U.S. Department of Veterans Affairs","keywords":"Calpain; Proteolysis; Biology; Cleavage (geology); Biochemistry; Threonine; Molecular biology; Serine; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003616128,0.000259288,0.0002125352,0.0000340126,0.0003808664,0.0001279917,0.000219653,0.0002753649,0.0004050025],"category_scores_gemma":[0.0003350638,0.0001640788,0.000259639,0.0001734895,0.0003132352,0.000005737152,0.0001919649,0.0004062748,0.00009437999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008109745,"about_ca_system_score_gemma":0.0002756903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008883531,"about_ca_topic_score_gemma":0.00002488991,"domain_scores_codex":[0.9981158,0.0002085012,0.0003708185,0.0004733369,0.0004483339,0.0003832164],"domain_scores_gemma":[0.9986488,0.00006769093,0.0001611796,0.0004769828,0.0003228858,0.0003224362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007547261,0.0001511918,0.0007310008,0.00001072385,0.0001063479,0.00009723424,0.00004148905,0.00005804633,0.971805,0.00007762719,0.02302565,0.003140995],"study_design_scores_gemma":[0.001594212,0.0002400603,0.004206749,0.00004833816,0.00005912542,0.002760175,0.0002527517,0.0000357058,0.8252575,0.0001001825,0.1651087,0.0003365482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905944,0.001686947,0.001910621,0.004451024,0.0003080834,0.0001724008,0.0000173645,0.00002090349,0.0008382828],"genre_scores_gemma":[0.9791902,0.0003228813,0.0006263015,0.002405894,0.002193275,0.0000101157,0.0002319811,0.00004802882,0.0149713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1465475,"threshold_uncertainty_score":0.6690937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119422036434269,"score_gpt":0.2309279464314017,"score_spread":0.219733726067059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}