{"id":"W3199132873","doi":"10.3389/fcell.2021.726205","title":"Extracellular Vesicles in Reprogramming of the Ewing Sarcoma Tumor Microenvironment","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Stand Up To Cancer; St. Baldrick's Foundation; American Association for Cancer Research","keywords":"Tumor microenvironment; Microvesicles; Cancer research; Metastasis; Stromal cell; Cancer; Reprogramming; Cancer-Associated Fibroblasts; Sarcoma; Cancer cell; Immune system; Biology; Medicine; Immunology; Cell; Pathology; microRNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002295242,0.0001889826,0.0001894028,0.0002128386,0.0001901613,0.0006065516,0.0001278208,0.0004286969,0.001012579],"category_scores_gemma":[0.0001841426,0.00008910301,0.0002965468,0.0001104946,0.0002200683,0.0005441204,0.0006492981,0.0005410882,0.0002615452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002799811,"about_ca_system_score_gemma":0.0001873776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001858633,"about_ca_topic_score_gemma":0.0002507962,"domain_scores_codex":[0.9998678,0.00003413057,0.00001005637,0.00002578592,0.00003247151,0.0000298224],"domain_scores_gemma":[0.9999439,0.00001156327,0.00001387062,0.000006878561,0.000009712063,0.00001423653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003501088,0.000078668,0.001087304,0.0007703551,0.00003793832,0.00117444,0.0002761507,0.000812537,0.9342146,0.009851192,0.001277273,0.05006937],"study_design_scores_gemma":[0.0000896306,0.000799739,0.01058865,0.0002781925,0.000128259,0.004048476,0.0006322587,0.003030183,0.7555188,0.006870347,0.2179641,0.00005135339],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8165587,0.1341226,0.02075162,0.002317623,0.001325531,0.0002228889,0.0007384812,0.0003917263,0.02357093],"genre_scores_gemma":[0.9737834,0.01859936,0.002331339,0.0003548785,0.00006606552,0.00005548089,0.0002703362,0.00003042237,0.004508838],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001012579,"threshold_uncertainty_score":0.003387451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286639290045797,"score_gpt":0.2436666684396584,"score_spread":0.2308002755392004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}